Christine Horejs, Chief Editor Nature Reviews Bioengineering at Springer Nature Group, shared on LinkedIn:
“Much of the effort in developing CAR-T therapies for solid tumours has focused on overcoming the barriers imposed by the tumour microenvironment.
However, in their new article, Yvonne Chen and Ryan Shih highlight an equally important question: how do CAR-T cells alter the tumour microenvironment itself?
The answer is complex. CAR-T cells can recruit endogenous immune cells, induce inflammatory signalling and remodel tumour vasculature, creating opportunities to boost anti-tumour responses. At the same time, these changes can also drive immunosuppression, increase toxicity and create new obstacles to efficacy.
The authors discuss how understanding this two-way interaction between CAR-T cells and the tumour microenvironment, and selecting the right combination of preclinical models to study it, could inform the design of safer and more effective next-generation cell therapies for solid tumours.”
Title: CAR-T cells reshape the tumour microenvironment
Authors: Ryan M. Shih, Yvonne Y. Chen
Other articles about CAR-T therapy on OncoDaily.