Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Cancer Research Institute (CRI) shared an article by Meriem Belabed on LinkedIn:
“Mature conventional dendritic cells (cDCs) are required to prevent autoimmunity and promote effective immune response against threats such as cancer, but the maturation process of cDCs remains poorly understood.
According to a new study from researchers including CRI-Merck Postdoctoral Fellow Dr. Camillia Azimi, former CRI-Bristol Myers Squibb Postdoctoral Fellow Dr. Nelson LaMarche, former Technology Impact Award Recipient Dr. Brian Brown, CRI Clinical Innovator Dr. Thomas Marron, CRI Scientific Advisory Council member Dr. Nina Bhardwaj, and CRI Scientific Advisory Council member Dr. Miriam Merad of Icahn School of Medicine at Mount Sinai, cDCs use cholesterol from outside the cell and internal production to form lipid structures on their surfaces, which assists them in maturing and activating immune responses.
This cholesterol-driven maturation process is controlled by the protein AXL, and deleting AXL can enhance cDC function, the study describes, improving anti-cancer immunity.“
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer.
Authors: Meriem Belabed, et al.
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