Patrick Hwu: How Can We Make CAR-NK Cell Therapy More Effective Against Tough Cancers?
Patrick Hwu, President and CEO at Moffitt Cancer Center, shared a post on LinkedIn:
“How can we make CAR-NK cell therapy more effective against tough cancers?
(CAR-NK = natural killer cells engineered with chimeric antigen receptors to target tumors)
A new study in Cancer Cell used CRISPR gene editing to search the entire genome of NK cells for genes that act like “brakes,” limiting their ability to kill cancer.
Knocking out key genes boosted NK cell metabolism, strengthened their cancer-killing power, and improved tumor penetration. When combined with CARs designed to recognize tumor proteins like CD70 and TROP2, the edited NK cells were even more potent.
This work shows how removing internal “brakes” could help create the next generation of stronger, longer-lasting, off-the-shelf cell therapies for both solid and blood cancers.
Read more in Cell by Cell Press.”
Title: Genome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potency
Authors: Alexander Biederstädt, Rafet Basar, Jeong-Min Park, Nadima Uprety, Rejeena Shrestha, Francia Reyes Silva, Merve Dede, John Watts, Sunil Acharya, Donghai Xiong, Bin Liu, May Daher, Hind Rafei, Pinaki Banerjee, Ping Li, Sanjida Islam, Huihui Fan, Mayra Shanley, Jingling Jin, Bijender Kumar, Vernikka Woods, Paul Lin, Silvia Tiberti, Ana Karen Nunez Cortes, Xin Ru Jiang, Inci Biederstädt, Patrick Zhang, Ye Li, Seema Rawal, Enli Liu, Luis Muniz-Feliciano, Gary M. Deyter, Elizabeth J. Shpall, Natalie Wall Fowlkes, Ken Chen, Katayoun Rezvani
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