OU Researchers Study Effects of Cannabis on Facial Wound Healing After Surgery

Preliminary data suggest a negative effect on wound healing

University of Oklahoma researchers are conducting a first-of-its-kind study to determine whether cannabis use affects recovery from the wounds associated with head and neck cancer surgery. The outcomes may have implications for other types of surgery and conditions.

Lurdes Queimado, M.D., Ph.D., and Mark Mims, M.D., have been funded by the Presbyterian Health Foundation in Oklahoma City to lead the research, which will include 220 adult patients undergoing surgery for head and neck cancer and reconstruction after the tumor removal. Many such surgeries compromise both appearance and physiological functions such as swallowing and breathing.

The research is unique in that it is prospective – patients will be followed for six months from the time of their treatment – rather than retrospectively looking at patient data. In addition, patients’ self-reporting of cannabis use will be biochemically verified through blood tests, which adds strength to the study.

“Research has shown that there is a high rate of cannabis use among cancer patients – more than 50% in some studies, and up to 80% among those who also use tobacco. But there is very little in the medical literature about how cannabis use affects the healing of wounds. Importantly, there are no prospective studies on this topic.

We believe the data that we gather will advance our understanding of how the diverse modes of cannabis use affect wound healing and establish a framework for related studies,” said lead principal investigator and Professor of Otolaryngology Lurdes Queimado, M.D., Ph.D. Queimado also directs the Tobacco Regulatory Science Lab at the TSET Health Promotion Research Center, a program of OU Health Stephenson Cancer Center.

Based on her preliminary research, Queimado hypothesizes that cannabis smoking negatively affects wound healing. Her initial studies, though limited, show that non-cancer patients who smoke cannabis have more inflammation and a decrease in immune system function, both of which could reduce wound healing and increase complications.

However, there are many factors to take into consideration, such as the mode in which patients consume cannabis and how often they use it. Queimado’s trial is designed with four groups of patients – those who use cannabis, those who use cannabis and tobacco, those who use tobacco only, and those who use neither.

“We will monitor each group of patients for infections, bleeding, medical complications, and scar healing, and we will assess how they are using cannabis, whether it’s smoking, vaping, or edibles, because they are very different in the effects they have. The ultimate goal is to have information to guide the patient,” she said.

Facial plastic and reconstructive surgeon Mark Mims, M.D., an assistant professor of otolaryngology and surgery, said this study is both relevant and timely.

“Patients come to my office and ask if using cannabis will affect their reconstructive surgery outcome, and we just don’t have enough data to counsel them with confidence,” Mims said.

While the main purpose of the study is to understand the effects of cannabis on wound healing in head and neck cancer patients, Queimado and her team will also gather information about patients’ responses to any treatment in addition to surgery, such as chemotherapy and radiation.

“I think this study has the potential to have major implications for other types of cancer and surgeries, but also for chronic diseases because inflammation and immunity play a significant role in many conditions, such as autoimmune diseases. I think there will be many opportunities for growth into other areas once we have established the framework of this study,” Queimado said.

About the University of Oklahoma

Founded in 1890, the University of Oklahoma is a public research university with campuses in Norman, Oklahoma City, and Tulsa. As the state’s flagship university, OU serves the educational, cultural, economic, and health care needs of the state, region, and nation. In Oklahoma City, OU Health Sciences is one of the nation’s few academic health centers with seven health profession colleges located on the same campus.

OU Health Sciences serves approximately 4,000 students in more than 70 undergraduate and graduate degree programs spanning Oklahoma City and Tulsa and is the leading research institution in Oklahoma. For more information about OU Health Sciences, visit www.ouhsc.edu.

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