Bishoy Morris Faltas: Paired Plus-Minus Sequencing for Accurate Dual-Strand DNA Analysis
Bishoy Morris Faltas, Chief Research Officer at the Englander Institute for Precision Medicine and an Associate Professor of Medicine and Cell and Developmental Biology at Weill Cornell Medicine, shared a post on X:
“Exciting collaboration with Alexandre Cheng, Dan Landau: ppmSeq, a dual-strand ultra-low error whole-genome sequencing(WGS) technology.
We applied it to tumor-uninformed WGS ctDNA from patients with urothelial cancer by focusing on the signal from APOBEC3-induced mutational signatures!
Many more exciting applications for this technology to read about. Full pre-print.”
Title: Paired plus-minus sequencing is an ultra-high throughput and accurate method for dual strand sequencing of DNA molecule
Authors: Alexandre Pellan Cheng, Itai Rusinek, Aaron Sossin, Adam J. Widman, Eti Meiri, Gat Krieger, Ori Hirschberg, Doron Shem Tov, Shlomit Gilad, Ariel Jaimovich, Omer Barad, Sammantha Avaylon, Srinivas Rajagopalan, Catherine Potenski, Tamara Prieto, Dennis J. Yuan, Rob Furatero, Alexi Runnels, Benjamin M. Costa, Jonathan E. Shoag, Majd Al Assaad, Michael Sigouros, Jyothi Manohar, Abigail King, David Wilkes, John Otilano, Murtaza S. Malbari, Olivier Elemento, Juan Miguel Mosquera, Nasser K. Altorki, Ashish Saxena, Margaret K. Callahan, Nicolas Robine, Soren Germer, Gilad D. Evrony, Bishoy M. Faltas, Dan-Avi Landau
Read The Full Article at bioRxiv.
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