Behnoush Abedi-Ardekani, Pathologist at IARC, shared on LinkedIn:
“Pleased to share our new publication in Nature Protocols: a standardized, pathologist-led workflow for pathology assessment and processing of frozen tumor tissues for whole-genome sequencing and cancer genomics.
One of the challenges in large-scale cancer genomics is often overlooked: the quality, consistency and traceability of the pathology information that sits upstream of the genomic data.
In the Mutographs project, we developed and implemented an integrated pathology-to-genomics workflow combining digital pathology, standardized pathology assessment and reporting, multidisciplinary review, tumor enrichment, data traceability and embedded quality-control checkpoints.
The workflow was designed to be reproducible, scalable and adaptable across tumor types and research settings, and is now established as the main approach for tissue-based cancer research at IARC, with project-specific adaptations.
Despite the increasing reliance on genomic technologies in cancer research, documented and standardized pathology frameworks specifically designed for large-scale research genomics remain relatively limited.
This work is our contribution to addressing that gap.
I am particularly proud of this publication because it represents several years of work bringing together pathology, digital technologies, laboratory science, data management and biobanking into one coherent research workflow – and because I had the opportunity to design, lead and supervise the development of the entire pathology-to-genomics framework.
Many thanks to all colleagues and collaborators who helped turn the concept into a functioning large-scale system.
Read Further:”
Title: Centralized processing of frozen tumor tissues for global cancer genomics
Authors: Behnoush Abedi-Ardekani, Arash Nikmanesh, Masoud Sotoudeh, Valerie Gaborieau, Farid Azmoudeh-Ardalan, Hiva Saffar, Stefano Serra, Christine Carreira, Priscilia Chopard, Sophie Ferlicot, Jean-Yves Scoazec, Christophe Lallemand, Elodie Colney, Sophie Guillot, Fatemeh Ghasemi-Kebria, Ana Carolina de Carvalho, Aida Ferreiro-Iglesias, Sandra Perdomo, Paul Brennan, Manuel Salto-Tellez and Gholamreaz Roshandel
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