Angela Mastronuzzi, Head of Neuro-Oncology Unit at Bambino Gesù Children’s Hospital and President of AIEOP, shared a post on LinkedIn:
“‘Needle-track metastasis in diffuse intrinsic pontine glioma: Need for a standardized surgical strategy?’ – published with Neuro-Oncology Advances of Oxford University Press in official partnership with the Society for Neuro-Oncology and the European Association of Neuro-Oncology (EANO).
Diffuse intrinsic pontine glioma (DIPG) remains uniformly lethal. Stereotactic biopsy confirms the diagnosis and enables molecular profiling. Metastasis along the biopsy track (BTM) has been reported only anecdotally; its prevalence, clinical relevance, and implications for treatment remain unclear.
A multicenter retrospective study in patients with confirmed DIPG and BTM was conducted based on central neuroradiologic review. Radiotherapy schedules were re-assessed to evaluate the feasibility of upfront biopsy track irradiation.
Key Points:
- Needle track metastasis occurs in approximately 5-10% of biopsied diffuse intrinsic
pontine glioma. - Including the biopsy track in upfront irradiation strategy is feasible.
- To reduce radiation exposure, the infratentorial biopsy access may be considered.”
Title: Needle-track metastasis in diffuse intrinsic pontine glioma: Need for a standardized surgical strategy?
Authors: Gunther Nussbaumer, Olga Nigro, Anke Barnbrock, Martin Benesch, Veronica Biassoni, Hans Christoph Bock, Andrea Carai, Anna Cavallo, Silvia Chiesa, Tommaso Giandini, Giovanna Stefania Colafati, Lucia De Martino, Martin Demmert, Valentina di Ruscio, Jeanne-Marie Franke, Lea L Friker, Gerrit H Gielen, Marion Hoffmann, Karolina Jablonska, Axel Karow, Michael Karremann, Kornelius Kerl, Friederike Knerlich-Lukoschus, Christof M Kramm, Mechthild Krause, Sebastian Makocki, Angela Mastronuzzi, Maura Massimino, Andrés Morales La Madrid, Emilia Pecori, Thomas Perwein, Torsten Pietsch, Dirk Rades, Claus Rödel, Vicente Santa-Maria Lopez, Elisabetta Schiavello, Rudolph Schwarz, Sergiu Scobioala, Thorsten Simon, Dorothee C Spille, Ulrich-Wilhelm Thomale, Arianna Trovò, Sabina Vennarini, André O von Bueren, Brigitte Bison, Chiara Valentini
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