Science

Akhil Kapoor: Triple Oral Metronomic Chemotherapy vs Chemotherapy of Physician Discretion After Failure of Platinum-Based Therapy in HNSCC

Akhil Kapoor/X

May 25, 2025, 06:47

Akhil Kapoor: Triple Oral Metronomic Chemotherapy vs Chemotherapy of Physician Discretion After Failure of Platinum-Based Therapy in HNSCC

Akhil Kapoor, Professor, Medical Oncologist at TMH Varanasi, shared a post on X:

“Just published in JCO Global Oncology

Our phase III METRO-CHASE trial shows triple oral metronomic chemotherapy significantly improves survival in platinum-refractory.

First-ever RCT showing non-immunotherapy significantly improves OS in platinum-refractory HNSCC.

It began in 2014 — drug repurposing and metronomic therapy research led by legends: Prof. Banavali, Prof. Prabhash, Vanita Noronha, Vijay Patil.

Oral-only treatment

Statistical improvement in OS (primary end point)

~$15/month

Better quality of life.

This success is the result of tireless work by a large and passionate team — including our clinicians, clinical trial coordinators, data entry operators, statisticians, and support staff. This achievement is truly shared.

Grateful to be part of this journey.

This is also FIRST RCT of our newly established center Mahamana Pt. Madan Mohan Malaviya Cancer Centre and Homi Bhabha Cancer Hospital.

6-month OS: 40.7% vs 26.2% (HR: 0.63; P=0.0001)
Restricted mean OS: 7.5 vs 5.4 months (P=0.036)
Consistent benefit across all subgroups
Immunotherapy: limited access, modest benefit for most.”

Title: Triple Oral Metronomic Chemotherapy Versus Chemotherapy of Physician Discretion After Failure of Platinum-Based Therapy in Advanced Head and Neck Cancer: A Phase III Randomized Study (METRO-CHASE Study)

Authors: Akhil Kapoor, Anuj Gupta, Bipinesh Sansar, et al.

You can read the Full Article on JCO Global Oncology.

Akhil Kapoor: Triple Oral Metronomic Chemotherapy vs Chemotherapy of Physician Discretion After Failure of Platinum-Based Therapy in HNSCC

More posts featuring Akhil Kapoor.

Akhil Kapoor Anuj Gupta Bipinesh Sansar cancer Head and Neck Cancer HNSCC OncoDaily Oncology Triple Oral Metronomic Chemotherapy Vanita Noronha Vijay Patil

A Call for Peace from the Frontlines of Pediatric Oncology by the POEM Group

Servier Acquires Precision Therapy for Acute Leukemias from BioNova Pharmaceuticals

Penn Medicine: Cancer Center Near Me

Elevating Childhood Cancer and Catastrophic Diseases in the Global NCD Agenda: Joint Call to Action

King Hussein Cancer Research Award: Don’t Miss Your Chance to Apply