Mario Mandalà: The Impact of SRT in Melanoma Patients with Brain Metastases Receiving Combo Immunotherapy
Mario Mandalà, Director of Medical Oncology at S.M. Misericordia Hospital and an Associate Professor of Medical Oncology at the University of Perugia, shared a post on LinkedIn:
“Just published in European Journal of Cancer our manuscript which addresses the impact of SRT in melanoma patients with brain metastases receiving Combo immunotherapy.
Main messages:
1) Stereotactic radiotherapy (SRT) may improve OS in patients with melanoma brain metastases (MBM) receiving COMBO.
2) The impact of SRT is independent of timing (concomitant vs sequential).
3) Number of MBM at baseline are associated with OS.
4) Regardless the number of MBM, patients may benefit from SRT.
Limitation:
- Retrospective study.
- Waiting for the results of prospective studies including ABC-X study and ETOP 19-21 USZ-STRIKE study.
Thanks to all coauthors for this academic study … a special thanks to Paolo A. Ascierto, Teresa Amaral, Georgina Long, Caroline Robert, Piotr Rutkowski , Sergi Chiara, Paul Lorigan, my friends of the Italian melanoma Intergroup.”
Combined immunotherapy with nivolumab and ipilimumab with and without sequential or concomitant stereotactic radiotherapy in patients with melanoma brain metastasis: an international retrospective study.
Authors: Mario Mandalà, Teresa Amaral, Piotr Rutkowski, Maria Chiara Sergi, Marie-Lena Rasch, Naima Benannoune, Patricio Serra, Maria Grazia Vitale, Diana Giannarelli, Ana Maria Arance, Eva Munoz Couselo, Bart Neyns, Iris Dirven, Marco Tucci, Michele Guida, Francesco Spagnolo, Ernesto Rossi, Paola Queirolo, Pietro Quaglino, Roberta Depenni, Joanna Placzke, Anna Maria Di Giacomo, Michele Del Vecchio, Alice Indini, Ines Pires da Silva, Alexander M. Menzies, Angela Hong, Paul Lorigan, Georgina V. Long, Caroline Robert, Paolo A. Ascierto.
You can read the full article on European Journal of Cancer.
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