Triparna Sen: Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma
Triparna Sen, Director of the Lung Cancer PDX Platform at the Icahn School of Medicine at Mount Sinai, shared an article by Utsav Sen, et al. on X:
“Excited to share our latest paper from the Sen Lab, now out in Cancer Research!
We uncover a metabolic vulnerability in KRAS/STK11/KEAP1 co-mutant NSCLC—a highly aggressive and treatment-refractory form of lung cancer. Our study uncovers how lipid desaturase SCD1 sustains redox balance and enables ferroptosis evasion in this subset.
These insights highlight a therapeutic opportunity and underscore the need for precision medicine to consider the metabolic rewiring of lung cancer subtypes. Data breakdown coming soon.
Huge thanks to the incredible Sen Lab team (especially Utsav Sen), and amazing collaborators at Icahn School of Medicine at Mount Sinai, Caris Life Sciences, and beyond. Grateful to National Cancer Institute and CDMRP for funding this work.”
SCD1 Inhibition Blocks the AKT-NRF2-SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma.
Authors: Utsav Sen, et al.
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