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Federico Monaca: Correlation between irAEs and survival outcomes in patients with ES-SCLC treated with first-line chemoimmunotherapy
Federico Monaca/LinkedIn
Apr 23, 2025, 10:42

Federico Monaca: Correlation between irAEs and survival outcomes in patients with ES-SCLC treated with first-line chemoimmunotherapy

Federico Monaca, Senior Clinical Research Fellow at The Christie NHS Foundation Trust, shared an article on LinkedIn:

“New Publication Alert.

I’m excited to share our largest‑to‑date, multicentre retrospective study published in the European Journal of Cancer:

“Correlation between irAEs and survival outcomes in patients with ES-SCLC treated with first-line chemoimmunotherapy.

Key Highlights:

  • The prognostic significance of immune‑related adverse events in ES‑SCLC has been unclear.
  • Patients who developed any irAE had significantly longer progression‑free survival (10.8 vs. 5.3 months) and overall survival (18.8 vs. 7.6 months) compared to those without.
  • Endocrine and cutaneous irAEs were particularly associated with better survival outcomes.
  • Importantly, neither high‑grade irAEs nor the use of corticosteroids for management adversely impacted survival.

Study Scope:

  • N = 399 patients.
  • 5 leading European centres (UK, Italy).
  • Median follow‑up: 15.0 months.

A lot of work remains to unravel the mechanisms behind irAEs, but these findings show we are heading in the right direction.

Special thanks to Martín Igor Gómez-Randulfe and Raffaele Califano for their support, and to all our co‑authors: Ana Sofia de Freitas Matos Parreira, Vito Longo, Domenico Galetta, Sara Pilotto, Ornella Cantale, Alessio Stefani, Emanuele Vita, Paul Taylor, Fábio Gomes, Laura Cove Smith, Yvonne  Summers, Giampaolo Tortora, Fiona Blackhall, Silvia Novello, and Emilio Bria.

Read the full article here.”

Federico Monaca: Correlation between irAEs and survival outcomes in patients with ES-SCLC treated with first-line chemoimmunotherapy

Correlation between irAEs and survival outcomes in patients with ES-SCLC treated with first-line chemoimmunotherapy.

Authors: Federico Monaca, et al.

Federico Monaca: Correlation between irAEs and survival outcomes in patients with ES-SCLC treated with first-line chemoimmunotherapy

Alessio Stefani Ana Sofia de Freitas Matos Parreira cancer chemoimmunotherapy Domenico Galetta Emanuele Vita Emilio Bria ES-SCLC European Journal of Cancer Fábio Gomes Federico Monaca fight against cancer Fiona Blackhall Giampaolo Tortora Global fight against cancer irAEs Laura Cove Smith Martín Igor Gómez-Randulfe OncoDaily Oncology Ornella Cantale Paul Taylor Raffaele Califano Sara Pilotto Silvia Novello survival outcomes The Christie NHS Foundation Trust Vito Longo Yvonne  Summers
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