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Patrick Hwu: The profound impact of stress on the immune landscape
Patrick Hwu/X
Apr 13, 2025, 13:18

Patrick Hwu: The profound impact of stress on the immune landscape

Patrick Hwu, President and CEO of Moffitt Cancer Center, shared an article by Cuilan Liu, et al. on LinkedIn:

“ScienceSaturday

Can chronic stress contribute to cancer progression?

A new study, using a mouse tumor model, shows chronic psychological stress can promote lung cancer growth by triggering the reprogramming of macrophages into a pro-tumor state. This shift is driven by a feedback loop between the stress-induced long non-coding RNA HIF1A-AS3 and HIF-1α, which alters the tumor microenvironment to favor immune evasion and cancer progression.

These findings highlight the profound impact of stress on the immune landscape and suggest targeting stress-activated pathways such as HIF1A-AS3/HIF-1α may offer new strategies for treatment.

Here’s a link to the study.”

Patrick Hwu: The profound impact of stress on the immune landscape

Chronic Stress Stimulates Protumor Macrophage Polarization to Propel Lung Cancer Progression.

Authors: Cuilan Liu, et al.

Patrick Hwu: The profound impact of stress on the immune landscape

cancer cancer progression fight against cancer Global fight against cancer HIF-1α HIF1A-AS3 Lung cancer OncoDaily Oncology Patrick Hwu RNA Science Saturday
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