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Al-Ola Abdallah: Plasma cell infiltration rates with 18F-FDG PET/CT in multiple myeloma

Al-Ola Abdallah/LinkedIn

Feb 11, 2025, 10:06

Al-Ola Abdallah: Plasma cell infiltration rates with 18F-FDG PET/CT in multiple myeloma

Al-Ola Abdallah, Associate Professor and Plasma Cell Disorder Program Director of the Division of HMCT at the University of Kansas Medical Center, shared a post on X about a recent paper by Özge Ulaş Babacan et al. published in MIRT:

“Relationship of Plasma Cell Infiltration Rates with 18F-FDG PET/CT.

Data and Hematological Parameters in Multiple Myeloma (MM).

Aim: To determine if 18F-FDG-PET/CT could potentially replace or reduce the need for repeated BMBx in diagnosing and monitoring MM!

Retrospective study of 71 patients diagnosed with MM between 2014 and 2021 who underwent PET/CT for staging and had not yet received treatment

Data collected included BM aspiration results, creatinine, albumin, calcium, neutrophil, lymphocyte, beta-2 microglobulin, and platelet values), and PET/CT scan results
The systemic inflammatory index (SII) was calculated using the formula: neutrophil x lymphocyte/ platelet
Bone lesion evaluation considered uptake greater than background bone marrow activity as positive. Diffuse bone marrow infiltration was defined as a bone marrow SUV max > hepatic SUV max.

Results:

No significant correlation between BM SUV max and plasma cell infiltration rate (p=0.07)
Significant correlation between visually increased BM uptake on PET/CT and higher plasma cell infiltration rates (p=0.037)
Significant correlation between the SUV max of lytic bone lesions showing increased 18F-FDG uptake and SII (p=0.025, r=0.330)
Significant correlation between BM SUV max and creatinine elevation (p=0.032)
PET/CT may be an advantage over BMBx in the diagnosis and evaluation of MM recurrence and may prevent repeated BMBx
The correlation between lytic lesion SUV max and SII suggests that higher lesion SUV max values and SII values could indicate a worse prognosis.
Elevated serum Cr levels correlated with BM SUV max, potentially linked to disease aggressiveness and poorer prognosis

Limitations: Beside its a retrospective study there was inability to reach the targeted number of patients and to evaluate the prognosis of the patients.”

“Relationship of Plasma Cell Infiltration Rates with 18F-FDG PET/CT Data and Hematological Parameters in Multiple Myeloma”

Authors: Özge Ulaş Babacan, Zekiye Hasbek, Hatice Terzi.

Al-Ola Abdallah: Plasma cell infiltration rates with 18F-FDG PET/CT in multiple myeloma