Lorenzo Gerratana/X
Dec 22, 2024, 09:59
CDK4/6 inhibitors: mechanisms of resistance and where to find them – Lorenzo Gerratana
Lorenzo Gerratana, Associate Professor of Medicine at University of Udine, posted on X about recent paper by him as co-author, titled “Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i): Mechanisms of resistance and where to find them” published on Science Direct.
Authors: L. Foffano, L. Cucciniello, E. Nicolò, I. Migliaccio, C. Noto, C. Reduzzi, L. Malorni, M. Cristofanilli, L. Gerratana, F. Puglisi
“CDK4/6 inhibitors: mechanisms of resistance and where to find them.
An outside of the box review.
Main takeaways:
RB1 loss in ctDNA predicts poorer PFS
CCNE1 gain impacts PALOMA-3 outcomes
Role of ESR1 still unclear.”
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