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Abner Antonio Murray highlights Brooke Felsheim and Charles Perou’s key findings at AACR25 on TNBC prognosis
Abner Antonio Murray/X
May 4, 2025, 02:40

Abner Antonio Murray highlights Brooke Felsheim and Charles Perou’s key findings at AACR25 on TNBC prognosis

Abner Antonio Murray, Hematology-Oncology Fellow at UNC Hematology-Oncology Fellowship, shared a post on X by UNC Lineberger, adding:

“Major shoutout to Brooke Felsheim and Dr. Charles Perou for a powerhouse presentation at AACR25!
Using paired DNA/RNA data from CALGB 40603, they revealed:
– Somatic mutation and copy number patterns mirroring TCGA-TNBC
– Homologous recombination deficiency ≠ predictor of pCR/EFS/OS
– Best prognostic model = RNA signatures + tumor stage (CD4 T cells, memory B cells, IgG ↑ survival; HER2 amp, ERBB2/CD25A ↓)
– Clinical + RNA features hit the highest C-index (0.68) in independent datasets—strong prognostic signal for stage II–III TNBC.
– A must-read in Nature, NPJ, Breast Cancer (PMID: 40057511)!”

Abner Antonio Murray

Prognostic and molecular multi-platform analysis of CALGB 40603 (Alliance) and public triple-negative breast cancer datasets

Authors: Brooke Felsheim et al.

Abner Antonio Murray

Quoting UNC Lineberger‘s post:

“Today at AACR25, Brooke Felsheim and Charles Perou, PhD, will be provide updates from SABCS24
– 10:15 a.m. – 11:45 a.m. CT
– Room S103″

Abner Antonio Murray

More posts featuring Abner Antonio Murray and TNBC on OncoDaily.

AACR AACR25 Adam D. Pfefferle Aranzazu Fernandez-Martinez Breast Cancer Brooke Felsheim CALGB cancer Charles Perou Cheng Fan George Somlo Katherine A Hoadley Lisa A. Carey Michele C. Hayward Naim U. Rashid Nature OncoDaily Oncology SABCS24 Sara M. Tolaney TNBC UNC Hematology-Oncology Fellowship UNC Lineberger William M. Sikov
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