Photo: Myeloma Research
May 27, 2023, 16:54
Is There An ‘Optimal’ Carfilzomib Dose For Relapsed Or Refractory MM?- Blood Cancer Today
A new study suggests there is an “optimal” dose of carfilzomib for patients with relapsed or refractory multiple myeloma (MM).
Xiang Zhou, MD, of the University Hospital of Würzburg in Germany; Andrej Besse, PhD, of Cantonal Hospital St. Gallen in Switzerland; and colleagues conducted the research because “optimal carfilzomib dosing is a matter of debate.”
They used 103 pairs of peripheral blood mononuclear cells from patients with relapsed or refractory MM to analyze the inhibition profiles of proteolytic proteasome subunits β5, β2, and β1 in response to carfilzomib. They compared low-dose carfilzomib (20 mg/m2 or 27 mg/m2) with high-dose carfilzomib (≥36 mg/m2) in the samples.
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