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A non-inferiority trial with protons doesn’t make sense – Dr. Nina Niu Sanford
Photo Nina Niu Sanford from UT Southwestern Medical Center
Jul 4, 2023, 05:30

A non-inferiority trial with protons doesn’t make sense – Dr. Nina Niu Sanford

A non-inferiority trial with protons doesn’t make sense, b/c they are much more expensive.

Need to show protons superior.

And the non-inferiority margin here is 1.53 – so PFS can be 53% worse with protons, & the study is still considered a proton win?

https://ncbi.nlm.nih.gov/pmc/articles/PMC5942581/

Source: Dr. Nina Niu Sanford / Twitter

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