Justin Taylor: We show that E7820, an anti-cancer sulfonamide, degrades RBM39 in patients with splicing factor mutant myeloid malignancies.

Justin Taylor, Assistant Professor at UM Sylvester Comprehensive Cancer Center and Principle Investigator at the Taylor Lab, made the following post on Twitter:

“Excited to see this paper in print Leukemia Journal! Many preclinical studies using RBM39 molecular glue degraders e.g indisulam. We show that E7820, an anti-cancer sulfonamide, degrades RBM39 in patients with splicing factor mutant myeloid malignancies.

Great collaboration between Memorial Sloan Kettering Cancer Center and Sylvester Comprehensive Cancer Center! Led by twitter-less Drs. Jan Bewersdorf and Eytan Stein, Abdel Wahab Lab, Lu Lab, Namrata Chandhok, Justin Watts and many others. Access to the full text here.”

Source: Justin Taylor/Twitter