Yelena Janjigian

Yelena Y. Janjigian, MD, is a Professor and Chief of the Gastrointestinal Oncology Service at Memorial Sloan Kettering Cancer Center in New York. She joined MSK’s faculty in 2009 and became chief in 2018. An expert in gastric and esophageal cancers, Dr. Janjigian led a pioneering combination of trastuzumab and pembrolizumab for HER2‑positive disease, achieving remarkable tumor responses and prompting a phase III follow‑up trial.

Present Title & Affiliation

Chief of the Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Professor of Medicine, Weill Cornell Medical College - New York, NY, USA

Innovation In Gastroesophageal Cancer

Selected Publications

Peer-reviewed Research Articles  

1. Janjigian YY, McDonnell K, Kris MG, Shen R, Sima CS, Bach PB, Rizvi NA, Riely GJ. Pack-years of cigarette smoking as a prognostic factor in patients with stage IIIB/IV nonsmall cell lung cancer. Cancer 2010; Feb 1; 116:670-675. PMCID:PMC2815173
2. Janjigian YY, Lee W, Kris MG, Miller VA, Krug LM, Azzoli CG, Senturk E, Calcutt MW, Rizvi NA. A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors. Cancer Chemother Pharmacol 2010; Apr; 65:833-8. PMID:19672598, NIHMS324552
3. De Braganca KC, Janjigian YY, Azzoli Cg, Kris MG, Pietanza MC, Noaln CP, Omuro AM, Holodny AI, Lassman AB. Efficacy and safety of bevacizumab in active brain metastases from non-small cell lung cancer. J Neurooncol. 2010 Dec; 100(3):443-7. PMCID: 3246379
4. Janjigian YY, Park BJ, Zakowski MF, Ladanyi M, Pao W, D’Angelo SP, Kris MG, Shen R, Zheng J, Azzoli CG. Impact on disease free survival of adjuvant erlotinib or gefitinib in patients with resected lung adenocarcinomas that harbor Epidermal Growth Factor Receptor (EGFR) mutations. J Thorac Oncol 2011 Mar; 6(3):569-75.PMID:21150674
5. Janjigian YY, Azzoli CG, Krug LM, Pereira LK, Rizvi NA, Pietanza MC, Kris MG, Ginsberg MS, Pao W, Miller VA, Riely GJ. Phase I/II trial of cetuximab and erlotinib in patients with lung adenocarcinoma and acquired resistance to erlotinib. Clin Cancer Res 2011 Apr 15;17(8):2521-7. PMID:21248303
6. Janjigian YY, Tang LH, Coit DG, Kelsen DP, Francone TD, Weiser MR, Jhanwar SC, Shah MA. MET expression and amplification in patients with localized gastric cancer. Cancer Epidemiol Biomarkers Prev (Cover Article). 2011 May; 20(5):1021-7. PMID:21393565
7. Shah MA, Khanin R, Tang L, Janjigian YY, Klimstra DS, Gerdes H, Kelsen DP. Molecular classification of gastric cancer: a new paradigm. Clin Cancer Res. 2011 May 1;17(9):2693- 701.PMCID: 3100216
8. Oxnard GR, Janjigian YY, Arcila ME, Sima CS, Kass SL, Riely GJ, Pao W, Kris MG, Ladanyi M, Azzoli CG, Miller VA. Maintained sensitivity to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer recurring after adjuvant erlotinib or gefitinib. Clin Cancer Res. 2011 Oct 1;17(19):6322-8 PMCID:3186869
9. Lowery MA, Kelsen DP, Stadler ZK, Yu KH, Janjigian YY, Ludwig E, D’Adamo DR, Salo-Mullen E, Robson ME, Allen PJ, Kurtz RC, O’Reilly EM. An Emerging Entity: Pancreatic Adenocarcinoma Associated with a Known BRCA Mutation: Clinical Descriptors, Treatment Implications, and Future Directions. Oncologist. 2011;16(10):1397-402 PMCID:3228075
10. Tafe LJ, Janjigian YY, Zaidinski M, Hedvat CV, Hameed MR, Tang LH, Hicks JB, Shah MA, Barbashina V. HER2 testing in gastric cancer: correlation between IHC and FISH. Arch Pathol Lab Med. 2011 Nov; 135(11):1460-5. PMID:22032573
11. Smyth EC, Capanu M, Janjigian YY, Kelsen DK, Coit D, Strong VE, Shah MA. Tobacco Use Is Associated with Increased Recurrence and Death from Gastric Cancer. Ann Surg Oncol. 2012 Jul; 19(7):2088-94. PMID:22395977
12. Janjigian YY, Werner D, Pauligk C, Steinmetz K, Kelsen DP, Jäger E, Altmannsberger HM, Robinson E, Tafe LJ, Tang LH, Shah MA, Al-Batran SE. Prognosis of Metastatic Gastric Cancer by HER2 Status: A European and US International Collaborative Analysis.” Ann Oncol. 2012 Oct;23(10):2656-62. PMID:22689179
13. Takezawa K, Pirazzoli V, Arcila ME, Nebhan CA, Song X, de Stanchina E, Ohashi K, Janjigian YY, Spitzler PJ, Melnick MA, Riely GJ, Kris MG, Miller VA, Ladanyi M, Politi K, Pao W. HER2 levels affect sensitivity and resistance to EGFR inhibition in EGFR mutant lung cancer. Cancer Discov. 2012 Oct; 2(10):922-33. PMID:22956644
14. D’Angelo SP, Janjigian YY, Ahye N, Riely GJ, Chaft JE, Sima CS, Shen R, Zheng J, Dycoco J, Kris MG, Zakowski MF, Ladanyi M, Rusch V, Azzoli CG. Distinct clinical course of EGFR- mutant resected lung cancers: results of testing of 1118 surgical specimens and effects of adjuvant gefitinib and erlotinib. J Thorac Oncol. 2012 Dec; 7(12):1815-22. PMID:23154553
15. Janjigian YY, Ku GY, Campbell JC, Shah MA, Capanu M, Kelsen DP, Ilson DH. Phase II trial of cetuximab plus cisplatin and irinotecan in patients with cisplatin and irinotecan-refractory metastatic esophagogastric cancer. Am J Clin Oncol. 2014 Apr;37(2):126-30. PMID:23211227
16. Janjigian YY, Villegas NV, Holland JP, Divilov V, Carlin SD, Gomes Da Gama EM, Chiosis G, Carbonetti G, de Stanchina E, Lewis JS. Monitoring Afatinib Treatment in HER2 Positive Gastric  Cancer with 18-F-FDG and 89-Zr-trastuzumab PET. J Nucl Med. 2013 Jun;54(6):936-43. PMID: 23578997
17. Lee KS, Hwang S, Hurtado Rua SM, Janjigian YY, Gollub MJ. Distinguishing Benign and Life- Threatening Pneumatosis Intestinalis in Patients with Cancer by CT Imaging Features. AJR Am J Roentgenol. 2013 May;200(5):1042-7 PMID: 23617487
18. Epstein AS, Volandes AE, Chen LY, Gary KA, Li Y, Agre P, Levin TT, Reidy DL, Meng RD, Segal NH, Yu KH, Abou-Alfa GK, Janjigian YY, Kelsen DP, O’Reilly EM. A randomized controlled trial of a cardiopulmonary resuscitation video in advance care planning for progressive pancreas and hepatobiliary cancer patients. J Palliat Med. 2013 Jun;16(6):623-31 PMID:  23725233
19. Gerber N, Ilson DH, Wu AJ, Janjigian YY, Kelsen DP, Zheng J, Zhang Z, Bains MS, Rizk N, Rusch VW, Goodman KA. Outcomes of induction chemotherapy followed by chemoradiation using  intensity-modulated radiation therapy for esophageal adenocarcinoma. Dis Esophagus. 2014 Apr;27(3):235-41.PMID: 23796070
20. Hudis C, Swanton C, Janjigian YY, Lee R, Sutherland SC, Chandarlapaty S, Lehman R, Hamilton R, Knowles J, Yan L, Sullivan D, Hudis C. A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors. Breast Cancer Res. 2013 Nov 19; 15(6):R110. PMID: 24252402
21. Park DJ, Yoon C, Thomas N, Ku GY, Janjigian YY, Kelsen DP, Ilson DH, Goodman KA, Tang LH, Strong VE, Coit DG, Yoon SS. Prognostic significance of targetable angiogenic and growth factors in patients undergoing resection for gastric and gastroesophageal junction cancers. Ann Surg Oncol. 2014 Apr;21(4):1130-7. PMID: 24370903
22. Yoon C, Park DJ, Schmidt B, Thomas NJ, Lee HJ, Kim TS, Janjigian YY, Cohen D, Yoon SS. CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signalling promotes chemotherapy resistance. Clin Cancer Res. 2014 Aug 1;20(15):3974-88 PMID: 24947926
23. Janjigian YY, Smith EF, Groen, HJM, Horn L, Gettinger S, Camidge DR, Riely GJ, Wang B, Fu Y, Chand VK, Miller VA, Pao W. Dual Inhibition of EGFR with Afatinib and Cetuximab in Kinase Inhibitor-Resistant EGFR-Mutant Lung Cancer with and without T790M Mutations. Cancer Discov. 2014 Sep;4(9):1036-45. PMID: 25074459
24. Afaneh C, Abelson J, Schattner M, Janjigian YY, Ilson D, Yoon SS, Strong VE. Esophageal Reinforcement with an Extracellular Scaffold During Total Gastrectomy for Gastric Cancer. Ann Surg Oncol. 2015 Apr;22(4):1252-7. PMID: 25319574
25. Selby LV, Vertosick EA, Sjoberg DD, Schattner MA, Janjigian YY, Brennan MF, Coit DG, Strong VE. Morbidity after Total Gastrectomy: Analysis of 238 Patients. J Am Coll Surg. 2015 May; 220(5):863-871.e2.  PMID: 25842172
26. Janjigian YY, Vakiani E, Ku GY, Herrera JM, Tang LH, Bouvier N, Viale A, Socci ND, Capanu M, Berger M, Ilson DH. Phase II Trial of Sorafenib in Patients with Chemotherapy Refractory Metastatic Esophageal and Gastroesophageal (GE) Junction Cancer PLoS One. 2015 Aug 14;10(8):e0134731. PMID: 26275293
27. Shah MA, Janjigian YY, Stoller RG, Shibata S, Kemeny M, Ritch PS , Krishnamurthi SS, Su YB, Capanu M, Kelsen DP.A Random Assignment, Multicenter Phase II study of modified Docetaxel, Cisplatin, and Fluorouracil (DCF) versus DCF plus growth factor support in patients with metastatic gastric adenocarcinoma: A Study of the US Gastric Cancer Consortium. J Clin Oncol. 2015 Nov 20;33(33):3874-9. PMID: 26438119
28. Chhabra A, Ong LT, Kuk D, Ku G, Ilson D, Janjigian YY, Wu A, Schöder H, Goodman KA. Prognostic significance of PET assessment of metabolic response to therapy in oesophageal squamous cell carcinoma. Br J Cancer. 2015 Dec 22;113(12):1658-65.. PMID: 26657654
29. Nguyen A, Loo JM, Mital R, Weinberg EM, Man FY, Zeng Z, Paty PB, Saltz L, Janjigian YY, de Stanchina E, Tavazoie SF. PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis. J Clin Invest. 2016 Feb;126(2):681-94. PMID: 26784545
30. Cao L, Selby LV, Hu X, Zhang Y, Janjigian YY, Tang L, Coit DG, Brennan MF, Strong VE. Risk factors for recurrence in T1-2N0 gastric cancer in the United States and China. J Clin Invest. 2016 Feb;126(2):681-94. PMID: 27040753
31. Ku, GY, Kriplani A, Janjigian YY, Kelsen DP, Rusch VW, Bains M, Chou J, Capanu M, Wu AJ, Goodman KA, Ilson DH. Change in chemotherapy during concurrent radiation followed by surgery after a suboptimal positron emission tomography response to induction chemotherapy improves outcomes for locally advanced esophageal adenocarcinoma. Cancer. 2016 Jul 1;122(13):2083-90. PMID: 27152857
32. Won E, Shah MA, Schöder H, Strong VE, Coit DG, Brennan MF, Kelsen DP, Janjigian YY, Tang LH, Capanu M, Rizk NP, Allen PJ, Bains MS, Ilson DH. Use of positron emission tomography scan response to guide treatment change for locally advanced gastric cancer: the Memorial Sloan Kettering Cancer Center experience. J Gastrointest Oncol. 2016 Aug;7(4):506-14. PMID: 27563439
33. Strong VE, Gholami S, Shah MA, Tang LH, Janjigian YY, Schattner M, Selby LV, Yoon SS, Salo- Mullen E, Stadler ZK, Kelsen D, Brennan MF, Coit DG. Total Gastrectomy for Hereditary Diffuse Gastric Cancer at a Single Center: Postsurgical Outcomes in 41 Patients. Ann Surg. 2016 Oct 17;266(6):1006-1012. PMID: 27759617
34. Ku GY, Bains MS, Park DJ, Janjigian YY, Rusch VW, Rizk NP, Yoon SS, Millang B, Capanu M, Goodman KA, Ilson DH. Phase II study of bevacizumab and preoperative chemoradiation for esophageal adenocarcinoma. J Gastrointest Oncol. 2016 Dec;7(6):828-837. PMID: 28078107
35. Ross DS, Zehir A, Cheng DT, Benayed R, Nafa K, Hechtman JF, Janjigian YY, Weigelt B, Razavi P, Hyman DM, Baselga J, Berger MF, Ladanyi M, Arcila ME. Next-Generation Assessment of ERBB2 (Human Epidermal Growth Factor Receptor 2) Amplification Status: Clinical Validation in the Context of a Hybrid Capture-Based, Comprehensive Solid Tumor Genomic Profiling Assay. J Mol Diagn. 2017 Mar;19(2):244-254. PMID: 28027945
36. Price EW, Carnazza KE, Carlin SD, Cho A, Edwards KJ, Sevak KK, Glaser JM, de Stanchina E, Janjigian YY, Lewis JS. 89-Zr-DFO-AMG102 Immuno-PET to Determine Local HGF Protein Levels in Tumors for Enhanced Patient Selection. J Nucl Med. 2017 Sep;58(9):1386-1394. PMID: 28280216
37. Lopez-Albaitero A, Xu H, Guo H, Wang L, Wu Z, Tran H, Chandarlapaty, Scaltriti M, Janjigian YY, de Stanchina E, Cheung NV. Overcoming resistance to HER2-targeted therapy with a novel HER2/CD3 bispecific antibody. Oncoimmunology. 2017 Mar 10;6(3):e1267891. PMID. 28405494
38. Zehir A, Benayed R, Shah RH, Syed A, Middha S, Kim HR, Srinivasan P, Gao J, Chakravarty D, Devlin SM, Hellmann MD, Barron DA, Schram AM, Hameed M, Dogan S, Ross DS, Hechtman JF, DeLair DF, Yao J, Mandelker DL, Cheng DT, Chandramohan R, Mohanty AS, Ptashkin RN, Jayakumaran G1, Prasad M1, Syed MH1, Rema AB1, Liu ZY1, Nafa K1, Borsu L1, Sadowska J, Casanova J, Bacares R, Kiecka IJ, Razumova A, Son JB, Stewart L, Baldi T, Mullaney KA, Al- Ahmadie H, Vakiani E, Abeshouse AA, Penson AV, Jonsson P, Camacho N, Chang MT, on HH1, Gross BE, Kundra R, Heins ZJ, Chen HW, Phillips S, Zhang H, Wang J, Ochoa A, Wills J, Eubank M, Thomas SB, Gardos SM, Reales DN, Galle J, Durany R, Cambria R, Abida W, Cercek A, Feldman DR, Gounder MM, Hakimi AA, Harding JJ, Iyer G, Janjigian YY, Jordan EJ, Kelly CM, Lowery MA, Morris LGT, Omuro AM, Raj N, Razavi P, Shoushtari AN, Shukla N, Soumerai TE, Varghese AM, Yaeger R, Coleman J, Bochner B, Riely GJ, Saltz LB, Scher HI, Sabbatini PJ, Robson ME, Klimstra DS, Taylor BS Baselga J Schultz N Hyman DM, Arcila ME, Solit DB, Ladanyi M1, Berger MF. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nat Med. 2017 Jun;23(6):703-713. PMID: 28481359
39. O’Donoghue JA, Lewis JS, Pandit-Taskar N, Fleming SE, Schoder H, Larson SM, Beylergil V1, Ruan S, Lyashchenko S, Zanzonico PB, Weber WA, Carrasquillo JA, Janjigian YY. Pharmacokinetics, biodistribution, and radiation dosimetry for 89Zr-trastuzumab in patients with esophagogastric cancer. J Nucl Med. 2017 Jun 21;59(1):161-166. PMID: 28637800
40. Chakravarty D, Gao J, Phillips SM, Kundra R, Zhang H, Wang J, Rudolph JE, Yaeger R, Soumerai T, Nissan MH, Chang MT, Chandarlapaty S, Traina TA, Paik PK, Ho AL, Hantash FM, Grupe A, Baxi SS, Callahan MK, Snyder A, Chi P, Danila D, Gounder M, Harding JJ, Hellmann MD, Iyer G, Janjigian YY, Kaley T, Levine DA, Lowery M, Omuro A, Postow MA, Rathkopf D, Shoushtari AN, Shukla N, Voss M, Paraiso E, Zehir A, Berger MF, Taylor BS, Saltz LB, Riely GJ, Ladanyi M, Hyman DM, Baselga J, Sabbatini P, Solit DB, Schultz N. OncoKB: A Precision Oncology Knowledge Base. JCO Precis Oncol 2017 July Jul;2017:PO.17.00011. doi: 10.1200/PO.17.00011. Epub 2017 May 16. PMID: 28890946
41. Hernandez JM1, Beylergil V, Goldman DA, van Beek E, Gonen M, Tang L, Downey R, Rizk N, Shah M, Strong V, Janjigian YY, Schöder H, Coit DG. Post-Treatment/Pre-operative PET Response Is Not an Independent Predictor of Outcomes for Patients With Gastric and GEJ Adenocarcinoma. Ann Surg. 2017 Aug 1;267(5):898-904 MID: 28767564
42. Horn L, Gettinger S, Camidge DR, Smit EF, Janjigian YY, Miller VA, Pao W, Freiwald M, Fan J, Wang B, Chand VK, Groen HJM.. Continued use of afatinib with the addition of cetuximab after progression on afatinib in patients with EGFR mutation-positive non-small-cell lung cancer and acquired resistance to gefitinib or erlotinib. Lung Cancer 2017 Nov; 113:51-58. PMID: 29110849
43. Schram AM, Reales D, Galle J, Cambria R, Durany R, Feldman D, Sherman E, Rosenberg J, D’Andrea G, Baxi S, Janjigian YY, Tap W, Dickler M, Baselga J, Taylor BS, Chakravarty D, Gao J, Schultz N, Solit DB, Berger MF, Hyman DM. Oncologist use and perception of large panel next-generation tumour sequencing. Ann Oncol. 2017 Sep 1;28(9):2298-2304. PMID: 28911072.
44. Jordan EJ, Lowery MA, Basturk O, Allen PJ, Yu KH, Tabar V, Beal K, Reidy DL, Yamada Y, Janjigian YY, Abou-Alfa GK, O’Reilly EM. Brain Metastases in Pancreatic Ductal Adenocarcinoma: Assessment of Molecular Genotype-Phenotype Features-An Entity With an Increasing Incidence? Clin Colorectal Cancer. 2018;17(2):e315-e321. PMID: 29496399
45. Barbetta A, Hsu M, Tan KS, Stefanova D, Herman K, Adusumilli PS, Bains MS, Bott MJ, Isbell JM, Janjigian YY, Ku GY, Park BJ, Wu AJ, Jones DR, Molena D. Definitive chemoradiotherapy versus neoadjuvant chemoradiotherapy followed by surgery for stage II to III esophageal squamous cell carcinoma. J Thorac Cardiovasc Surg. 2018 Jun; 55(6):2710-2721.e3. PMID: 29548582
46. van Beek EJAH, Hernandez JM, Goldman DA, Davis JL, McLoughlin K, Ripley RT, Kim TS, Tang LH, Hechtman JF, Zheng J, Capanu M, Schultz N, Hyman DM, Ladanyi M, Berger MF, Solit DB, Janjigian YY, Strong VE. Rates of TP53 Mutation are Significantly Elevated in African American Patients with Gastric Cancer. Ann Surg Oncol. 2018 Jul;25(7):2027-2033. PMID: 31898094
47. Barbetta A, Nobel TB, Sihag S, Hsu M, Tan KS, Bains MS, Isbell JM, Janjigian YY, Wu AJ, Bott MJ, Jones DR, Molena D. Neutrophil to Lymphocyte Ratio as Predictor of Treatment Response in Esophageal Squamous Cell Cancer. Ann Thorac Surg. 2018 May 5;106(3):864-871. PMID: 29738752
48. Janjigian YY, Sanchez-Vega F, Jonsson P, Chatila W, Hechtman J, Ku G, Riches J, Tuvy Y, Kundra R, Bouvier N, Vakiani E, Gao J, Heins Z, Gross B, Kelsen D, Zhang L, Strong V, Schattner M, Gerdes H, Coit D, Bains M, Satdler Z, Rusch V, Jones D, Molena D, Shia J, Robson M, Capanu M, Middha S, Zehir A, Hyman D, Scaltriti M, Ladanyi M, Rosen N, Ilson D, Berge M,  Tang L, Taylor B, Solit D, Schultz N. Genetic predictors of response to systemic therapy in esophagogastric cancer. Cancer Discov. 2018 Jan;8(1):49-58. PMID: 29122777
49. Strong VE, Gholami S, Shah MA, Tang LH, Janjigian YY, Schattner M, Selby LV, Yoon SS, Salo-Mullen E, Stadler ZK, Kelsen D, Brennan MF, Coit DG. Total Gastrectomy for Hereditary Diffuse Gastric Cancer at a Single Center: Postsurgical Outcomes in 41 Patients. Ann Surg. 2017 Dec;266(6):1006-1012. PMID: 27759617
50. Fan PD, Narzisi G, Jayaprakash AD, Venturini E, Robine N, Smibert P, Germer S, Yu HA, Jordan EJ, Paik PK, Janjigian YY, Chaft JE, Wang L, Jungbluth AA, Middha S, Spraggon L, Qiao H, Lovly CM, Kris MG, Riely GJ, Politi K, Varmus H, Ladanyi M.  YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics. Proc Natl Acad Sci USA. 2018 June 26;115(26):E6030-6038. PMID: 29875142
51. Mondaca S, Margolis M, Sanchez-Vega F, Jonssson P, Riches JC, Ku GY, Hechtman JF, Tuvy Y, Berger MF, Shah MA, Kelsen DK, Ilson DH, Yu K, Goldberg Z, Epstein A, Desai A, Chung V, Chou JF, Capanu M, Solit DB, Schultz N, Janjigian YY. Phase II study of trastuzumab with modified docetaxel, cisplatin, and 5 fluorouracil in metastatic HER2-positive gastric cancer. Gastric Cancer 2018 August 7;22(2):355-362 PMID: 30088161
52. Janjigian YY, Bendell J, Calvo E, Kim J,. Ascierto P, Sharma P, Ott P, Peltola K, Jaeger D,  Evans T, DeBraud, F, Chau I, Tschaika M, Harbison C, Dorange C, Le D. CheckMate 032 Study: Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Patients with Metastatic Esophagogastric Cancer. J Clin Oncol. 2018 October 1;36(28):2836-2844. PMID: 30110194
53. Harding JJ, Nandakumar S, Armenia J, Khalil DN, Albano M, Ly M, Shia J, Hechtman JF, Kundra R, El Dika I, Do RK, Sun Y, Kingham TP, D’Angelica MI, Berger MF, Hyman DM, Jarnagin WR, Klimstra DS, Janjigian YY, Solit DB, Schultz N, Abou-Alfa GK. Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next Generation Sequencing for Matching Patients to Targeted and Immune Therapies. Clin Cancer Res. 2018 October 29;25(7):2116-2126. PMID: 30373752
54. Harding JJ, Lowery MA, Shih AH, Schvartzman JM, Hou S, Famulare C, Patel M, Roshal M, Do RK, Zehir A, You D, Selcuklu SD, Viale A, Tallman MS, Hyman DM, Reznik E, Finley LWS, Papaemmanuil E, Tosolini A, Frattini MG, MacBeth KJ, Liu G, Fan B, Choe S, Wu B, Janjigian YY, Mellinghoff IK, Diaz LA, Levine RL, Abou-Alfa GK, Stein EM, Intlekofer AM. Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition. Cancer Discovery. 2018 Dec;8(12):1540-1547 PMID: 30355724
55. Latham A, Srinivasan P, Kemel Y, Shia J, Bandlamudi C, Mandelker D, Middha S, Hechtman J, Zehir A, Dubard-Gault M, Tran C, Stewart C, Sheehan M, Penson A, DeLair D, Yaeger R, Vijai J, Mukherjee S, Galle J, Dickson MA, Janjigian YY, O’Reilly EM, Segal N, Saltz LB, Reidy-Lagunes D, Varghese AM, Bajorin D, Carlo MI, Cadoo K, Walsh MF, Weiser M, Aguilar JG, Klimstra DS, Diaz LA Jr, Baselga J, Zhang L, Ladanyi M, Hyman DM, Solit DB, Robson ME, Taylor BS, Offit K, Berger MF, Stadler ZK. Microsatellite Instability Is Associated with the Presence of Lynch Syndrome Pan-Cancer. J Clin Oncol. 2018 October 30;37(4)286-295. PMID: 30376427
56. Greally M, Chou J, Molena D, Rusch VW, Bains MS, Park BJ, Wu AJ, Goodman KA, Kelsen DP, Janjigian YY, Ilson DH, Ku GY. PET scan-directed chemoradiation for esophageal squamous cell carcinoma: no benefit for a chance in chemotherapy in PET non-responders. J Thorac Oncol. 2018 November 1;14(3):540-546. PMID: 30391577
57. Sanchez-Vega F, Hechtman J, Castel P, Ku GY, Tuvy Y, Imtiaz T, Bouvier N, Soon J, Vakiani E, Schattner M, Kelsen D, Lefkowitz R, Brown K, Lacouture M, Capanu M,. Berger M, Lacobuzio-Donahue C, Ilson D, De Stanchina E, Lewis J, Carrasquillo J, Taylor B,. Solit D., Schultz N, Scaltriti M, Janjigian YY. EGFR and MET determine outcome in ERBB2 esophagogastric cancer. Cancer Discov. 2018 November 21;9(2):199-209. PMID: 30463996
58. Pereira PMR, Sharma SK, Carter LM, Edwards KJ, Pourat J, Ragupathi A, Janjigian YY, Durack JC, Lewis JS. Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy. Nat Commun. 2018 December 3;9(1):5137. PMID: 30510281
59. Samstein RM, Lee CH, Shoushtari AN, Hellmann MD, Shen R, Janjigian YY, Barron DA, Zehir A, Jordan EJ, Omuro A, Kaley TJ, Kendall SM, Motzer RJ, Hakimi AA, Voss MH, Russo P, Rosenberg J, Iyer G, Bochner BH, Bajorin DF, Al-Ahmadie HA, Chaft JE, Rudin CM, Riely GJ, Baxi S, Ho AL, Wong RJ, Pfister DG, Wolchok JD, Barker CA, Gutin PH, Brennan CW, Tabar V, Mellinghoff IK, DeAngelis LM, Ariyan CE, Lee N, Tap WD, Gounder MM, D’Angelo SP, Saltz L, Stadler ZK, Scher HI, Baselga J, Razavi P, Klebanoff CA, Yaeger R, Segal NH, Ku GY, DeMatteo RP, Ladanyi M, Rizvi NA, Berger MF, Riaz N, Solit DB, Chan TA, Morris LGT. Tumor mutational load predicts survival after immunotherapy across multiple cancer types. Nat Genet. 2019 January 14; 51 202-206. https://doi.org/10.1038/s41588-018-0312-8
60. Nobel TB, Livschitz J, Eljalby M, Janjigian YY, Bains MS, Adusumilli PS, Jones DR, Molena D. Unique Considerations for Females Undergoing Esophagectomy. Annals of Surgery. 2019 January 17;272(1):113-117. PMID: 30672802
61. Samstein RM, Lee CH, Shoushtari AN, Hellmann MD, Shen R, Janjigian YY, Barron DA, Zehir A, Jordan EJ, Omuro A, Kaley TJ, Kendall SM, Motzer RJ, AriHakimi A, Voss MH, Russo P, Rosenberg J, Iyer G, Bochner BH, Bajorin D, Al-Ahmadie HA, Chaft JE, Rudin CM, Riely GJ, Baxi S, Ho AL, Wong RJ, Pfister DG, Wolchok JD, Barker CA, Gutin PH, Brennan CW, Tabar V, Mellinghoff IK, DeAngelis LM, Ariyan CE, Lee N, Tap WD, Grounder MM, D’Angelo SP, Saltz L, Stadler ZK, Scher HI, Baslega J, Razavi P, Klebanoff CA, Yaeger R, Segal NH, Ku GY, DeMatteo RP, Ladanyi M, Rizvi N, Berger MF, Riaz N, Solid DB, Chan TA, Morris LGT. Tumor Mutational Load Predicts Survival After Immunotherapy Across Multiple Cancer Types. Nat Gen. 2019 February 1;51(2):202-206. PMID: 30643254
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112. Maron SB, Walid C, Walch H, Chou JF, Ceglia N, Ptashkin R, Do RKG, Paroder V, Pandit-Taskar N, Lewis JS, De Castria TB, Sabwa S, Socolow F, Feder L, Thomas J, Schulze I, Kim K, Elzein A, Bojilova V, Zatzman M, Bhanot U, Nagy RJ, Lee J, Simmons M, Segal M, Ku GY, Ilson DH, Capanu M, Hectman JF, Merghoub T, Shah S, Schultz N, Soliy DB, Janjigian YY. Determinants of surivial in HER2+ metastatic esophagogastric cancer. Clincal Cancer Res. 2023 July 5. doi: 10.1158/1078-04322. CCR-22-3769.
113. Boerner T, Carr R, Hsu M, Tan KS, Sigel C, Tang L, Harrington C, Ku GY, Ilson DH, Janjigian YY, Wu AJ, Sihag S, Bains MS, Bott MJ, Isbell JM, Park BJ, Jones DR, Molena D. Prognostic value of circumferential radial margin involvement in esophagectomy for esophageal cancer: A case series.International Journal of Surgery. 2023 August 7. doi:10.1097/JS9.0000000000000609.
114. Cytryn SL, Moy RH, Cowzer D, Shah RH, Chou JF, Joshi SS, Ku GY, Maron SB, Desai A, Yang J, Sugarman R, Rao D, Goldberg Z, Charalambous C, Lapshina M, Antoine A, Socolow F, Trivedi N, Capanu M, Gerdes H, Schattner MA, Simmons M, Lacouture ME, Paroder V, Tang LH, Shia J, Ilson DH, Solit DB, Berger MF, Janjigian YY. First-line regorafenib with nivolumab and chemotherapy in advanced oesophageal, gastric, or gastro-oesophageal junction cancer in the USA: a single-arm, single-centre, phase 2 trial. Lancet Oncol. 2023 September 1. https://doi.org/10.1016/S1470-2045(23)00358-3.
115. Moehler M, Xiao H, Blum SI, Elimova E, Cella D, Shitara K, Ajani JA, Janjigian YY, Garrido M, Shen L, Yamaguchi K, Liu T, Schenker M, Kowalyszyn R, Bragagnoli AC, Bruges R, Montesarchio V, Pazo-Cid R, Hunter S, Davenport E, Wang J, Kondo K, Li M, Wyrwicz. Health-related quality of life with nivolumab plus chemotherapy versus chemotherapy in patients with advanced gastric/gastroesophageal junction cancer or esophageal adenocarcinoma from CheckMate 649. J Clin Oncol. 2023 September 15. https://doi.org/10.1200/JCO.23.00170.
116. Harrold EC, Foote MB, Rousseau B, Walch H, Kemel Y, Richards AL, Keane F, Cercek A, Yaeger R, Rathkopf D, Segal NH, Patel Z, Maio A, Borio M, O’Reilly EM, Reidy D, Desai A, Janjigian YY, Murciano-Goroff YR, Carlo MI, Latham A, Liu YL, Walsh MF, Ilson D, Rosenberg JE, Markowitz AJ, Weiser MR, Rossi AM, Vanderbilt C, Mandelker D, Bandlamudi C, Offit K, Berger MF, Solit DB, Saltz L, Shia J, Diaz LA, Stadler ZK. Neoplasia risk in patients with Lynch syndrome treated with immune checkpoint blockade. Nat Med 29, 2458-2463. 2023 October 16. https://doi.org/10.1038/s41591-023-02544-9.
117. Janjigian YY, Kawazoe A, Bai Y, Xu J, Lonardi S, Metges JP, Yanez P, Wyrwicz LS, Shen L, Ostapenko Y, Bilici M, Chung HC, Shitara K, Qin SK, Van Cutsem E, Tabernero J, Li K, Shih CS, Bhagia P, Rha SY. Pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma:interim analyses from the phase 3 KEYNOTE-811 randomised placebo-controlled trial. The Lancet. 2023 October 20.  https://doi.org/10.1016/S0140-6736(23)02033-0.
118. Magahis PT, Maron SB, Cowzer D, King S, Schattner M, Janjigian YY, Faleck, Laszkowska M. Impact of Helicaobacter pylori infection status on outcomes among patients with advanced gastric cancer treated with immune checkpoint inhibitors. J Immunother Cancer. 2023 October 11 (1):e007699. doi: 10.1136/jitc-2023-007699.
119. Shitara K, Rha SY, Wyrwicz LS, Oshima T, Karaseva N, Osipov M, Yasui H, Yabusakui H, Afanasyev S, Park YK, Al-Batran SE, Yoshikawa T, Yanez, P, Di Bartolomeo M, Lonardi S, Tabernero J, Van Cutsem E, Janjigian YY, Oh DY, Xu J, Fang X, Shih CS, Bhagia P, Bang YJ. Neoadjuvant and adjuvant pembrolizumab plus chemotherapy in locally advanced gastric or gastro-oesophageal cancer (KEYNOTE-585): an interim analysis of the multicentre, double-blind, randomized phase 3 study. The Lancet. 2023 December 19. https://doi.org/10.1016/S1470-2045(23)00541-7.
120. Fick CN, Dunne EG, Sihag S, Molena D, Cytryn SL, Janjigian YY, Wu AJ, Worrell SG, Hofstetter WL, Jones DR, Gray KD. Immunotherapy for Resectable Locally Advanced Esophageal Carcinoma. The Annals of Thoracic Surgery. 2024 February 5. https://doi.org/10.1007/s10120-023-01457-3.
121. Janjigian YY, Ajani JA, Moehler M, Shen L, Garrido M, Gallardo C, Wyrwicz, Yamaguchi K, Cleary JM, Elimova E, Karamouzis M, Bruges R, Skoczylas T, Bragagnoli, Liu T, Tehfe M, Zander T, Kowalyszyn R, Pazo-Cid R, Schenker M, Feeny K, Wang R, Lei M, Chen C, Nathani R, Shitara K. First-line nivolumab plus chemotherapy for advanced gastric, gastroesophageal junction and esophageal adenocarcinoma: 3-year follow-up of the phase III CheckMate 649 trial. J Clin Oncol. 2024 February 21. https://doi.org/10.1200/JCO.23.01601
122. Kitagawa Y, Matsuda S, Gotoda T, Kato K, Wijnhoven B, Lordick F, Bhandari P, Kawakubo H, Kodera Y, Terashima M, Muro K, Takeuchi H, Mansfield PF, Kurokawa Y, So J, Monig SP, Shitara K, Rha SY, Janjigian Y, Takahari D, Chau I, Sharma P, Li J, De Manzoni G, Nilsson M, Kassab P, Hofstetter WL, Smyth EC, Lorenzen S, Doki Y, Law S, Oh DY, Ho KY, Koike T, Shen L, Van Hillegersberg R, Kawakami H, Xu RH, Yahagi N, Lee YY, Singh R, Ryu MH, Ishihara R, Xiao Z, Kusano C, Grabsch HI, Hara H, Mukaisho KI, Makino T, Kanda M, Booka E, Suzuki S, Hatta W, Kato M, Maekawa A, Kawazoe A, Yamamoto S, Nakayama I, Narita Y, Yang HK, Yoshida M, Sano T. Clinical Practice guidelines for esophagogastric junction cancer: Upper GI Oncology Summit 2023. Gastric Cancer. 2024 February 22. https://doi.org/10.1007/s10120-023-01457-3.
123. Vitiello GA, Jayaprakasam VS, Tang LH, Schattner MA, Janjigian YY, Ku GY, Maron SB, Schoder H, Larson SM, Gonen M, Datta J, Coit DG, Brennan M, Strong VE. Patient metabolic profile defined by liver and muscle 18 F‑FDG PET avidity is independently associated with overall survival in gastric cancer. Gastric Cancer. 2024 March 4. https://doi.org/10.1007/s10120-024-01485-7.
124.  Cytryn SL, Pandit-Taskar N, Lumish MA, Maron SB, Gu P, Ku GY, Chou JF, Capanu M, Antonie A, Loegel D, Feder L, Philemond S, Lyashchenko SK, Lewis JS, Paroder V, Srivastava A, Tang LH, Schoder H, Janjigian YY. 18F-BMS-986229 PET to Assess Programmed-Death Ligand 1 Status in Gastroesophageal Cancer. Journal of Nuclear Medicine. 2024 March 21. https://doi.org/10.2967/jnumed.123.267186
125. Gupta A, Michelini F, Shao H, Yeh C, Drago JZ, Liu D, Rosiek E, Romin Y, Ghafourian N, Thyparambil S, Misale S, Park W, de Stanchina E, Janjigian YY, Yaeger R, Li BT, Chandarlapaty S. EGFR-directed antibodies promote HER2 ADC internalization and efficacy. Cell Rep Med. 2024 Oct 11:101792. https://doi.org/10.1016/j.xcrm.2024.101792
126. Semaan K, Nawfal R, Nally E, Janjigian YY, Robert C, Peters S, Powles T, Choueiri TK. Landscape of subsequent therapies in perioperative immunotherapy trials across multiple cancer types. Lancet Oncol. 2024;25(7):890-901. doi:10.1016/S1470-2045(24)00513-8.
127. Sewell M, Toumbacaris N, Tan KS, Bahadur N, Philip J, Shah NJ, Niederhausern A, Tavarez Martinez C, Zheng H, Boerner T, Janjigian YY, Maron SB, Bott MJ, Gray KD, Park BJ, Sihag S, Jones DR, Ku GY, Wu AJ, Molena D. Esophagectomy may have a role in stage IV esophageal adenocarcinoma. J Thorac Cardiovasc Surg. 2024 Nov 22:S0022-5223(24)01087-0. doi: 10.1016/j.jtcvs.2024.11.015.
128. Magahis PT, Cornet N, Tang L, Arora K, Hingorani N, King S, Markowitz AJ, Schattner M, Shimada S, Maron SB, Vardhana S, Lumish M, Cercek A, Janjigian YY, Coit D, Mendelsohn RB, Berger MF, Strong VE, Stadler ZK, Laszkowska M. Differences in Ancestry and Presence of Gastric Precursor Lesions in Individuals With Young- and Average-Onset Gastric Cancer. Cancer Med. 2024 Dec;13(23):e70451. doi: 10.1002/cam4.70451. PMID: 39629931; PMCID: PMC11615756.
129. Abate M, Stroobant EE, Fei T, Lin YH, Shimada S, Drebin H, Chen E, Tang LH, Shah SP, Wolchok JD, Janjigian YY, Strong VE, Vardhana SA. Host Tissue Factors Predict Immune Surveillance and Therapeutic Outcomes in Gastric Cancer. Cancer Immunol Res. 2025 Apr 2;13(4):591-601. doi: 10.1158/2326-6066.CIR-23-0563. PMID: 39786344; PMCID: PMC11964842.
130. White C, Jayaprakasam VS, Tenet M, Tang LH, Schattner MA, Janjigian YY, Maron SB, Schöder H, Larson SM, Gönen M, Datta J, Coit DG, Mauguen A, Strong VE, Vitiello GA. PET-CT-based host metabolic (PETMet) features are associated with pathologic response in gastroesophageal adenocarcinoma. Eur J Surg Oncol. 2025 Jan 8;51(5):109589. doi: 10.1016/j.ejso.2025.109589. Epub ahead of print. PMID: 39808889.
131. Shitara K, Janjigian YY, Ajani J, Moehler M, Yao J, Wang X, Chhibber A, Pandya D, Shen L, Garrido M, Gallardo C, Wyrwicz L, Yamaguchi K, Skoczylas T, Bragagnoli A, Liu T, Schenker M, Yañez P, Kowalyszyn R, Karamouzis M, Zander T, Feeney K, Elimova E, Doshi P, Li M, Lei M. Nivolumab plus chemotherapy or ipilimumab in gastroesophageal cancer: exploratory biomarker analyses of a randomized phase 3 trial. Nat Med. 2025 Mar 7. doi: 10.1038/s41591-025-03575-0. Epub ahead of print. PMID: 40055521.
132. Janjigian YY, Cecchini M, Shitara K, Enzinger PC, Wainberg ZA, Chau I, Satoh T, Lee J, Nebozhyn M, Loboda A, Kobie J, Vajdi A, Shih CS, Cristescu R, Cao ZA. Genomic Landscape of Late-Stage Gastric Cancer: Analysis From KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 Studies. JCO Precis Oncol. 2025 Mar;9:e2400456. doi: 10.1200/PO-24-00456. Epub 2025 Mar 21. Erratum in: JCO Precis Oncol. 2025 Apr;9:e2400266. doi: 10.1200/PO-25-00266. PMID: 40117530; PMCID: PMC11949223.
133. Janjigian YY, Cecchini M, Shitara K, Enzinger PC, Wainberg ZA, Chau I, Satoh T, Lee J, Nebozhyn M, Loboda A, Kobie J, Vajdi A, Shih CS, Cristescu R, Cao ZA. Erratum: Genomic Landscape of Late-Stage Gastric Cancer: Analysis From KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 Studies. JCO Precis Oncol. 2025 Apr;9:e2400266. doi: 10.1200/PO-25-00266. Epub 2025 Apr 23. Erratum for: JCO Precis Oncol. 2025 Mar;9:e2400456. doi: 10.1200/PO-24-00456. PMID: 40267390.
134. Cercek A, Foote MB, Rousseau B, Smith JJ, Shia J, Sinopoli J, Weiss J, Lumish M, Temple L, Patel M, Wilde C, Saltz LB, Argiles G, Stadler Z, Artz O, Maron S, Ku G, Gu P, Janjigian YY, Molena D, Iyer G, Coleman J, Abida W, Cohen S, Soares K, Schattner M, Strong VE, Yaeger R, Paty P, Shcherba M, Sugarman R, Romesser PB, Zervoudakis A, Desai A, Segal NH, El Dika I, Widmar M, Wei I, Pappou E, Fumo G, Aparo S, Gonen M, Gollub M, Jayaprakasham VS, Kim TH, Garcia Aguilar J, Weiser M, Diaz LA Jr. Nonoperative Management of Mismatch Repair-Deficient Tumors. N Engl J Med. 2025 Apr 27. doi: 10.1056/NEJMoa2404512. Epub ahead of print. PMID: 40293177.
135. Walch HS, Borpatragohain R, Jee J, Chatila W, Fong C, Maron SB, Ku GY, Ilson DH, Janjigian YY, Wu AJ, Shah P, Coit DG, Bains MS, Rusch VW, Park BJ, Bott MJ, Gray K, Jones DR, Berger M, Schultz N, Strong VE, Molena D, Sihag S. Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer. Clin Cancer Res. 2025 Apr 29:OF1-OF10. doi: 10.1158/1078-0432.CCR-24-3473. Epub ahead of print. PMID: 40299774.
136. Sundar R, Nakayama I, Markar SR, Shitara K, van Laarhoven HWM, Janjigian YY, Smyth EC. Gastric cancer. Lancet. 2025 May 1:S0140-6736(25)00052-2. doi: 10.1016/S0140-6736(25)00052-2. Epub ahead of print. PMID: 40319897.

Reviews and Editorials

1. Janjigian YY, Nimer S: A role for Wnt signaling in adult T-cell leukaemia Leuk Res 29:475-6, 2005.
2. Janjigian YY, Miller VA.: Do molecular diagnostics add to clinical characteristics in selecting patients for gefitinib treatment? Nat Clin Pract Oncol. 2008 Jan;5(1):10-1
3. Janjigian YY. Lapatinib in gastric cancer: What is the LOGiCal next step? J Clin Oncol. 2016 February 10. PMID: 26700116
4. Elimova E, Janjigian YY, Mulcahy M, Catenacci DV, Blum MA, Almhanna K, Hecht JR, Ajani JA.It Is Time to Stop Using Epirubicin to Treat Any Patient With Gastroesophageal Adenocarcinoma. J Clin Oncol. 2017 Feb. PMID: 28129519
5. Mondaca S, Yoon SS, Strong VE, Ilson DH, Greally M, Janjigian YY. Microsatellite Instability as a Predictive Biomarker for Adjuvant Chemotherapy in Gastric Cancer: Are we there yet? Ann Surg. 2018 November 22. PMID: 30480560
6. Mondaca S, Janjigian YY. Cancer. 2019 Apr 15;125(8):1214-1217. doi: 10.1002/cncr.31940. Epub 2019 Jan 22. No abstract available. PMID: 30668898
7. M. Lumish, N. Tarazona, Janjigian YY. Postoperative ctDNA monitoring: a canary in a coalmine. Annals of Oncology. 2021 January 5. ISSN 0923-7534
8. Janjigian YY, Wolchok JD, Ariyan CE. Eradicating micrometastases with immune checkpoint blockade: Strike while the iron is hot. Cancer Cell. 2021 Jun 14;39(6):738-742. doi: 10.1016/j.ccell.2021.05.013. PMID: 34129818.
9. Reynolds JV, Cowzer D, Janjigian YY. Should chemoradiotherapy be standard to maximise cure in localised gastro-oesophageal cancer? Lancet Oncol. 2022 Jul;23(7):847-849. doi: 10.1016/S1470-2045(21)00753-1. PMID: 35772454.
10. Lumish, M., Maron, S., Paroder, V., Chou, J., Capanu, M., Philemond, S., O’Donoghue, J., Schoder, H., Lewis, J., Lyaschenko, S., Pandit-Taskar, N., Janjigian YY. Noninvasive assessment of human epidermal growth factor receptor 2 (HER2) in esophagogastric cancer using Zr-trastuzumab PET: a pilot study. Journal of Nuclear Medicine. 2022 November. doi: 10.2967/jnumed.122.264470

Book Chapters

1. Kumar N, Janjigian YY, Schwartz DR. Paradoxical worsening of shock after the use of a percutaneous mechanical thrombectomy device in a postpartum patient with a massive pulmonary embolism. Chest 2007 Aug;132(2):677-9.
2. Janjigian YY and Shah MA: Molecularly targeted therapies in advanced gastric cancer. Minerva Gastroenterol e Dietologica. 2011 Mar; 57(1):75-88.
3. Janjigian YY and Bains, MS: Perioperative Therapy for Localized Esophageal Cancer. Book Chapter in ECAB Clinical Update: surgical Gastroenterology and Liver Transplantation, Elsevier 2011. (Book chapter)
4. Ang C, Janjigian YY, Shamseddine A, Tawil A, Lowery MA, Intlekofer A, Faraj W, Al-Olayan A, Tang L, O’Reilly EM, Geara F, Al-Kutoubi A, Kelsen DP, Abou-Alfa GK.A case of advanced gastric cancer. Gastrointest Cancer Res. 2012 Mar; 5(2):59-63. PMID: 22690259
5. Janjigian YY and Kelsen DP; Genomic Dysregulation in Gastric Tumors. J Surg Oncol. 2013 Mar;107(3):237-42 PMID: 23042588
6. Janjigian YY. Gastric Cancer, Pocket Oncology. 2014.
7. Jhaveri K, Ochiana SO, Dunphy MP, Gerecitano JF, Corben AD, Peter RI, Janjigian YY, Gomes-Dagama EM, Koren J 3rd, Modi S, Chiosis G. Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions. Expert Opin Investig Drugs. 2014 Mar 26. PMID: 24669860
8. Janjigian YY. Role of HER2 in Gastric Cancers, Gastric Cancer: Principles and Practice. 2015. (Book chapter)
9. Won E, Janjigian YY, Ilson DH. HER2 directed therapy for gastric/esophageal cancers. J Gastrointest Oncol. 2016 Aug;7(4):506-14. PMID: 24811128
10. Aguiar PN Jr, Muniz TP, Miranda RR, Tadokoro H, Forones NM, Monteiro ID, Castelo-Branco P Janjigian YY, de Mello RA. Current advances in target therapies for metastatic gastric cancer: improving patient care. Future Oncol. 2016 Mar;12(6):839-54. PMID: 26838766.
11. Kelly CM, Janjigian YY. The genomics and therapeutics of HER2-positive gastric cancer-from trastuzumab and beyond. J Gastrointest Oncol. 2016 Oct 7. PMID: 27747089
12. Lordick F, Janjigian YY. Clinical impact of tumour biology in the management of gastroesophageal cancer. Nat Rev Clin Oncol. 2016 Jun;13(6):348-60. PMID: 26925958
13. Lordick F, Shitara K, Janjigian YY. New Agents on the Horizon in Gastric Cancer. Ann Oncol. 2017 Aug 1;28(8):1767-1775. PMID: 28184417
14. Janjigian YY, Braghiroli MI. Current Progress in Human Epidermal Growth Factor Receptor2 Targeted Therapies in Esophagogastric Cancer. Surg Oncol Clin N Am. 2017 Apr;26(2):313-324.PMID: 28279471
15. Ajani JA, Lee J, Sano T, Janjigian YY, Fan D, Song S. Gastric adenocarcinoma. Nat Rev Dis Primers. 2017 Jun 1;3:17036 PMID: 28569272
16. Janjigian YY, Bissig M, Curigliano G, Coppola J, Latymer M. Talking to patients about biosimilars. Future Oncol. 2018 Jun 1. PMID: 29856243
17. Cohen NA, Strong VE, Janjigian YY.  Checkpoint blockage in Esophagogastric Cancer. J Surg Oncol. 2018 Jun 7. Review. PMID: 29878357
18. De Mello RA, Lordick F, Muro K, Janjigian YY. Current and Future Aspects of Immunotherapy for Esophageal and Gastric Malignancies. Am Soc Clin Oncol Educ Book. 2019 Jan. Review. PMID: 31099644
19. Nagavarakishore Pillarsetty,Komal Jhaveri ,Tony Taldone Eloisi Caldas-Lopes , Blesida Punzalan , Suhasini Joshi , Alexander Bolaender Mohammad M. Uddin , Anna Rodina , Pengrong Yan , Anson Ku , Thomas Ku , Smit K. Shah , Serge Lyashchenko , Eva Burnazi , Tai Wang , Nicolas LeCompte , Janjigian YY , Anas Younes, Connie W. Batlevi, Monica L. Guzman, Gail J. Roboz , Jacek Koziorowski, Pat Zanzonico , Mary L. Alpaugh ,Adriana Corben, Shanu Modi , Larry Norton , Steven M. Larson ,Jason S. Lewis, Gabriela Chiosis , John F. Gerecitano , Mark P.S. Dunphy: Paradigms for Precision Medicine in Epichaperome Cancer Therapy. 2019
20. Paradigms for Precision Medicine in Epichaperome Cancer Therapy. Pillarsetty N, Jhaveri K, Taldone T, Caldas-Lopes E, Punzalan B, Joshi S, Bolaender A, Uddin MM, Rodina A, Yan P, Ku A, Ku T, Shah SK, Lyashchenko S, Burnazi E, Wang T, Lecomte N, , Janjigian YY, Younes A, Batlevi CW, Guzman ML, Roboz GJ, Koziorowski J, Zanzonico P, Alpaugh ML, Corben A, Modi S, Norton L, Larson SM, Lewis JS, Chiosis G, Gerecitano JF, Dunphy MPS.Cancer Cell. 2019 Oct 21. pii: S1535-6108(19)30427-1. doi: 10.1016/j.ccell.2019.09.007. PMID: 31668946
21. Nakamura, Y., Kawazoe, A., Lordick, F., Janjigian YY, Shitara, K. Biomarker-targeted therapies for advanced-stage gastric and gastro-oesophageal junction cancers: an emerging paradigm. Nat Rev Clin Oncol (2021).
22. Moy R.H., Janjigian Y.Y. (2021) Stomach: The Standard of Care ± HER2. Cancer Immunotherapy. Springer, Cham. https://doi.org/10.1007/13905_2021_4
23. Guercio BJ, Iyer G, Kidwai WZ, Lacouture ME, Ghafoor S, Rossi AM, Assis DN, Chen YB, Busam KJ, Janjigian YY, Jhaveri K, Feldman DR, Capozzi A, Figueroa V, Bajorin DF, Rosenberg JE, Hollmann TJ, Funt SA. Treatment of Metastatic Extramammary Paget Disease with Combination Ipilimumab and Nivolumab: A Case Report. Case Rep Oncol. 2021 Mar 12;14(1):430-438. doi: 10.1159/000514345. PMID: 33790764.
24. Nakamura Y, Kawazoe A, Lordick F, Janjigian YY, Shitara K. Biomarker-targeted therapies for advanced-stage gastric and gastro-oesophageal junction cancers: an emerging paradigm. Nat Rev Clin Oncol. 2021 Mar 31. doi: 10.1038/s41571-021-00492-2. PMID: 33790428.
25. de Castria TB, Tang L, Queiroz MM, Awni BM, Paroder V, Shamseddine A, Bariani GM, Mukherji D, Matar CF, Fernandes GDS, El-Olayan A, Sabatin F, Elias R, Gupta R, Janjigian YY, Abou-Alfa GK. Hepatoid esophagogastric adenocarcinoma and tumoral heterogeneity: a case report. J Gastrointest Oncol 2021 Sept 30. doi: 10.21037/jgo-21-287.
26. Cowzer D, Janjigian YY. Top advances in esophageal/gastroesophageal junction cancers in 2021. Cancer. 2022 Feb 18. doi: 10.1002/cncr.34140. Epub ahead of print. PMID: 35179774.
27. Yang J, Janjigian YY. Immune checkpoint blockade and targeted therapies in esophageal cancer. Thoracic Surgery Clinics. 2022 July 2. doi: 10.1016/j.thorsurg.2022.07.002.

Oncologist Near Me – Yelena Janjigian: A Global Leader in Gastrointestinal Oncology

• Office address: 300 E66th Street, BAIC 1001, New York, NY 10065
• Office telephone:  +1-646-888-4286
• Work email: [email protected]