Premal Patel, Chief Medical Officer at Elephas, shared on LinkedIn:
“Excited to share our latest publication in Cell Reports Medicine!
Immune checkpoint inhibitors have transformed cancer treatment, yet predicting which patients will benefit remains a major challenge.
Our study demonstrates the promise of functional precision medicine – moving beyond static biomarkers to directly measure how live patient tumor tissue responds to immunotherapy ex vivo. Using the Elephas elive platform, we observed 93% concordance with clinical outcomes in an initial clinical cohort.
These findings represent an important step toward more personalized advancement of immunotherapy.
Congratulations to the entire team and our collaborators!”
Interesting findings from this study:
- Identified potential responders missed by conventional biomarkers: The platform detected patients who may benefit from immune checkpoint inhibitors despite testing negative for established predictive biomarkers.
- Developed a simplified eight-cytokine classifier: The elive index uses changes in eight cytokines to classify tumors as likely responders or nonresponders, achieving an area under the curve of 0.99 for distinguishing the response groups identified by clustering.
- Enabled testing with routine clinical biopsies: The platform was developed using live tumor fragments from standard-of-care biopsies, offering a potential alternative to approaches that require larger surgical tumor samples.
- Demonstrated potential to identify objective responders: In the clinical cohort, the platform correctly identified 10 of 12 patients who had an objective response to immunotherapy, suggesting potential value in selecting patients for treatment
Read the full article:
Title: Prediction of immunotherapy response using live tumor fragments from routine clinical biopsies
Authors: David Braun, Nicholas Dana, Hilary R. Hernan, Shalini Sahni, Christina M. Scribano, Christin Johnson, Lindsey Vedder, Erika von Euw, Julie Zweng, Ellen Wargowski, Aishwarya Sunil, Deepa Sharma, Josh Routh, Katherine Rexroad, Amreen Nasreen, Payton McDonnell, Victor Jergens, Catarina Costa, Richard Zuniga, Giuseppe V. Toia, Paras M. Patel, Stephanie McGregor, Robert C.G. Martin, II, Umair Majeed, Debabrata Mukhopadhyay, Yanyan Lou, Nima Kokabi, James W. Jakub, David Hays, Andrew K. Godwin, Victoria Giffi, Alexander Gelbard, Andreas Friedl, Emma Kate Duimstra, Roxana S. Dronca, Ruqin Chen, Heather Chalfin, Santanu Bhattacharya, Barbara Broome, Hani M. Babiker, Tarun Chandra, Sean Caenepeel, Laura C.F. Hrycyniak, Chetan Sood, Hilario Ramos, Premal Patel, Pooja Advani, Hinco J. Gierman, Janis Taube
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