Top Articles Suggested by Vivek Subbiah

Vivek Subbiah, Chief of Early-Phase Drug Development at the Sarah Cannon Research Institute, shared some top articles.

1. “Very interesting!

A paper in Nature Medicine suggests that large language models can do more than generate text — they can also predict a person’s aging status!”

Title: Unexpected ability of large language models: predicting aging status

Journal: Nature Medicine

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2. “Innovative ways to target (K)RAS dependencies!

Nice read in Nature Cancer.”

Title: Innovative ways to target (K)RAS dependencies

Journal: Nature Cancer

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3. “A federated deep learning approach applied to human proteomic data, acquired using two distinct proteomic technologies from 40 tumor cohorts across eight countries, enabled accurate cancer histopathologic subtyping while preserving data privacy.

This approach will enable the privacy-compliant development of large-scale proteomic artificial intelligence models, including foundation models, across institutions globally.”

Title: Federated Deep Learning Enables Cancer Subtyping by Proteomics

Journal: Cancer Discovery

Authors: Zhaoxiang Cai, Emma L. Boys, Zainab Noor, Adel T. Aref, Dylan Xavier, Natasha Lucas, Steven G. Williams, Jennifer M.S. Koh, Rebecca C. Poulos, Yangxiu Wu, Michael Dausmann, Karen L. MacKenzie, Adriana Aguilar-Mahecha, Carolina Armengol, Maria M. Barranco, Mark Basik, Elise D. Bowman, Roderick Clifton-Bligh, Elizabeth A. Connolly, Wendy A. Cooper, Bhavik Dalal, Anna DeFazio, Martin Filipits, Peter J. Flynn, J. Dinny Graham, Jacob George, Anthony J. Gill, Michael Gnant, Rosemary Habib, Curtis C. Harris, Kate Harvey, Lisa G. Horvath, Christopher Jackson, Maija R.J. Kohonen-Corish, Elgene Lim, Jia (Jenny) Liu, Georgina V. Long, Reginald V. Lord, Graham J. Mann, Geoffrey W. McCaughan, Lucy Morgan, Leigh Murphy, Sumanth Nagabushan, Adnan Nagrial, Jordi Navinés, Benedict J. Panizza, Jaswinder S. Samra, Richard A. Scolyer, John Souglakos, Alexander Swarbrick, David Thomas, Rosemary L. Balleine, Peter G. Hains, Phillip J. Robinson, Qing Zhong, Roger R. Reddel

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4.“Interesting Nature publication on the development of orally bioavailable macrocyclic peptide inhibitors of cyclin A/B–RxL interactions, elucidating their mechanism of inducing apoptosis in SCLCs with high E2F activity and demonstrate their efficacy in SCLC models.

Looking forward to the clinical translation.”

Title: Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors

Journal:  Nature

Authors: Shilpa Singh, Catherine E. Gleason, Min Fang, Yasmin N. Laimon, Vishal Khivansara, Shanhai Xie, Yavuz T. Durmaz, Aniruddha Sarkar, Kenneth Ngo, Varunika Savla, Yixiang Li, Muhannad Abu-Remaileh, Xinyue Li, Marie-Anais Locquet, Bishma Tuladhar, Ranya Odeh, Frances Hamkins-Indik, Daphne He, Miles W. Membreno, Meisam Nosrati, Nathan N. Gushwa, Siegfried S. F. Leung, Breena Fraga-Walton, Luis Hernandez, Miguel P. Baldomero, Bryan M. Lent, David Spellmeyer, Joshua F. Luna, Dalena Hoang, Yuliana Gritsenko, Manesh Chand, Megan K. DeMart, Sammy Metobo, Chinmay Bhatt, Justin A. Shapiro, Kai Yang, Nathan J. Dupper, Andrew T. Bockus, Jinshu Fang, Ramesh Bambal, Peadar Cremin, John G. Doench, James B. Aggen, Li-Fen Liu, Bernard Levin, Evelyn W. Wang, Iolanda Vendrell, Roman Fischer, Benedikt Kessler, Prafulla C. Gokhale, Sabina Signoretti, Alexander Spektor, Constantine Kreatsoulas, Marie Evangelista, Rajinder Singh, David J. Earp, Deepak Nijhawan, Pablo D. Garcia, Matthew G. Oser

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5. Title: Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth

Journal: Nature Cancer

Authors: Ying Li, Hao Yu, Zi-Ming Li, Kai-Wen Yin, Shi-Yang Jin, Chao-Chao Chen, Ming-Shi Tan, Chuan-Jie Zhang, Xun-Hua Liu, Wei-Peng Li, Jian-Ming Yang, Ai-Jun Zhou, Xiang Zhang, En-De Ni, Meng-Ling Wang, Hui Mo, Chao Qin, Jian Hu, Shu-Ji Li, Tian-Ming Gao, Jian-Ming Li

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6. Title: Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune response

Journal: Nature Cancer

Authors: Jinpeng Han, Shenqiang Wang, Weifeng Fang, Yinxian Yang, Ruyi Zhou, Yuqi Zhang, Jicheng Yu, Ruikang Tang, Zhaoming Liu, Zhen Gu

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7.“Clinical decision-making in oncology is complex, requiring the integration of multimodal data and multidomain expertise.

A paper published in Nature Cancer shows how they developed and evaluated an autonomous clinical artificial intelligence (AI) agent leveraging GPT-4 with multimodal precision oncology tools to support personalized clinical decision-making.”

Title: Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology

Journal: Nature Cancer

Authors: Dyke Ferber, Omar S. M. El Nahhas, Georg Wölflein, Isabella C. Wiest, Jan Clusmann, Marie-Elisabeth Leßmann, Sebastian Foersch, Jacqueline Lammert, Maximilian Tschochohei, Dirk Jäger, Manuel Salto-Tellez, Nikolaus Schultz, Daniel Truhn, Jakob Nikolas Kather

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8. Title: Is There a Role for Mifamurtide in Nonmetastatic High-Grade Osteosarcoma? Results From the Italian Sarcoma Group (ISG/OS-2) and Spanish Sarcoma Group (GEIS-33) Trials

Journal: JCO

Authors: Emanuela Palmerini, Cristina Meazza, Angela Tamburini, Catalina Márquez-Vega, Gianni Bisogno, Franca Fagioli, Virginia Ferraresi, Giuseppe Maria Milano, Luca Coccoli, Alba Rubio-San-Simón, Oscar Gallego, María Esther Llinares Riestra, Carla Manzitti, Jaume Mora, Mª Ángeles Vaz-Salgado, Roberto Luksch, Cristina Mata, Michela Pierini, Elisa Carretta, Marilena Cesari, Anna Paioli, Andrea Marrari, Katia Scotlandi, Massimo Serra, Sebastian Dorin Asaftei, Marco Gambarotti, Piero Picci, Stefano Ferrari, Claudia Valverde, Toni Ibrahim, Javier Martín Broto

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