Caryn Lerman/LinkedIn
Jun 12, 2025, 15:30
Caryn Lerman Highlighted Study Published in Viruses on WAVE1 and WAVE2 Roles in HPV16 Cell Entry
Caryn Lerman, Director of Norris Comprehensive Cancer Center at Keck Medicine of USC, shared a post on LinkedIn about a recent article published in Viruses:
“Published in the journal Viruses, Dr. W. Martin Kast, co-leader of the Tumor Immunology and Microenvironment Program, along with first author Dr. Daniel Fernandez and their team, found that two proteins, WAVE1 and WAVE2, actually “wave” to HPV, to assist the virus to get into human cells.
After HPV enters these cells, it usually makes more copies of itself; but, occasionally, it transforms normal cells into cancer cells, which can lead to cervical and throat cancer. When these proteins were removed, the virus had a much harder time getting into the cells.
The team also demonstrated that WAVE1, WAVE2, actin, and HPV16 all gather at the same spot on the cell surface before the virus enters. These findings suggest that WAVE1 and WAVE2 play a key role in helping HPV16 enter cells by altering the cell’s shape.
To see this demonstrated, go here.
Read the full publication here.”
Watch video attached to this post.
Title: Human Papillomavirus Type 16 Stimulates WAVE1- and WAVE2-Dependent Actin Protrusions for Endocytic Entry
Journal: Viruses
Authors: Daniel J. Fernandez, Stephanie Cheng, Ruben Prins, Sarah F. Hamm-Alvarez, W. Martin Kast
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