Tyler Shropshire: Nothing Short of Extraordinary
Tyler Shropshire, Vice President, Global Biopharma Business Development, Head of Real World Data at Caris Life Sciences, shared on LinkedIn about a recent paper by Eghbal Amidi et al. published on Nature:
“The progress made in digital pathology over the last ~5 years is nothing short of extraordinary. Starting with the basic adoption of digitized WSI’s as standard, the field has moved from assisting pathologists in tumor detection/grading to going beyond what the human eye can see and mining for features in multimodal datasets that are prognostic indicators or predictive biomarkers and embedding them downstream into clinical trial workflows.
This week, the team at Caris Life Sciences published a paper in Nature Precision Oncology demonstrating the detection of ROS1 and ALK fusions in NSCLC.
While exceedingly rare, patients who harbor these mutations can often benefit the most from targeted therapy. Along with impressive ROC AUC’s for ALK/ROS1, ‘Trade-off plots’ are presented that demonstrate how the fine tuning of our model can alter false vs true negatives for a given marker – an important consideration for any deployment in the real world.
Congratulations to all of the authors – George Sledge, Matthew Oberley, Ming Chen, Eghbal Amidi, Mukund V., Tommy Boucher, Brian Lamon, Nicolas Stransky Mark Miglarese, Timmy Samec”
Title: Predicting ROS1 and ALK fusions in NSCLC from H&E slides with a two-step vision transformer approach
Matthew Oberley, Chief Clinical Officer at Caris Life Sciences, shared Tyler Shropshire’s post:
“Imagine running these algorithms on the scanner as the image is being produced…so-called edge computing. This would allow screening patients for clinical trials in real time wherever the scanners are installed.”
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