Shaida Ouladan: Characterizing the spatial landscape of gut
Shaida Ouladan, Molecular Pathology Scientist, shared a post on LinkedIn about a recent paper by Toufic Mayassi et al. published in Nature:
“Characterizing the spatial landscape of gut!
A recent study published in Nature uncovers the intricate spatial and cellular landscape of the intestine, showcasing how the gut adapts to its environment through robust and resilient mechanisms.
Highlights include:
- Spatial transcriptomics: Comprehensive mapping of the murine intestine, revealing how specific regions adapt uniquely to the microbiota and other environmental pressures.
- Middle colon adaptation: Identification of a microbiota-driven, immune-mediated adaptation in the middle colon, highlighting unique structural cell states.
- Resilience under stress: The gut’s transcriptional landscape demonstrates remarkable recovery following inflammation, showcasing its resilience.
This work bridges the gap between regional gut physiology and its implications in diseases like IBD, Crohn’s, and Ulcerative Colitis. A pivotal step towards tailored therapeutics and Precision Medicine in gut health.”
“Spatially restricted immune and microbiota-driven adaptation of the gut”
Authors: Toufic Mayassi, Chenhao Li, Åsa Segerstolpe, Eric Brown, Rebecca Weisberg, Toru Nakata, Hiroshi Yano, Paula Herbst, David Artis, Daniel Graham and Ramnik Xavier.
For more posts like this, visit oncodaily.com.
-
ESMO 2024 Congress
September 13-17, 2024
-
ASCO Annual Meeting
May 30 - June 4, 2024
-
Yvonne Award 2024
May 31, 2024
-
OncoThon 2024, Online
Feb. 15, 2024
-
Global Summit on War & Cancer 2023, Online
Dec. 14-16, 2023