Insight

Yan Leyfman

Jun 12, 2025, 15:53

Yan Leyfman Highlighted Study Published in Science on Vascularized Cardiac and Hepatic Organoids

Yan Leyfman, Co-founder and Executive Director of MedNews Week, shared a post on LinkedIn:

“Breakthrough in Organoid Vascularization!

A major step forward in modeling human development.

Stanford researchers have successfully created vascularized cardiac and hepatic organoids from human pluripotent stem cells, mimicking early human organ development with remarkable fidelity.

Why it matters:
– Recapitulates early cardiac and hepatic development (Carnegie Stages 9–20)
– Mimics multicellular environments including myocardium, endocardium and hepatic lineages
– Enables scalable, reproducible, and functional in vitro models
– Offers a powerful platform for drug testing, disease modeling & regenerative strategies

This work paves the way for deeper insights into human organogenesis and brings us closer to real-world applications in personalized medicine.”

Title: Gastruloids enable modeling of the earliest stages of human cardiac and hepatic vascularization

Journal: Science

Authors: Oscar J. Abilez, Huaxiao Yang, Yuan Guan, Mengcheng Shen, Zehra Yildirim, Yan Zhuge, Ravichandra Venkateshappa, Shane R. Zhao, Angello H. Gomez, Marcel El-Mokahal, Logan Dunkenberger, Yoshikazu Ono, Masafumi Shibata, Peter N. Nwokoye, Lei Tian, Kitchener D. Wilson, Evan H. Lyall, Fangjun Jia, Hung Ta Wo, Gao Zhou, Bryan Aldana, Ioannis Karakikes, Detlef Obal, Gary Peltz, Christopher K. Zarins, Joseph C. Wu

Read the full article.

Science

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Angello H. Gomez Bryan Aldana cancer Christopher K. Zarins Detlef Obal Evan H. Lyall Fangjun Jia Gao Zhou Gary Peltz Huaxiao Yang human pluripotent stem cells Hung Ta Wo Ioannis Karakikes Joseph C. Wu Kitchener D. Wilson Lei Tian Logan Dunkenberger Marcel El-Mokahal Masafumi Shibata MedNews Week Mengcheng Shen OncoDaily Oncology Organoid Vascularization Oscar J. Abilez personalized medicine Peter N. Nwokoye Ravichandra Venkateshappa Shane R. Zhao Stanford University stem cells Yan Leyfman Yan Zhuge Yoshikazu Ono Yuan Guan Zehra Yildirim

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