Samuel Hume: Top 5 advances in medicine this week
Samuel Hume, Fellow at The Foulkes Foundation and pursuing PhD in the University of Oxford’s Department of Oncology, shared a post on X:
“Top 5 advances in medicine this week:
1. A tissue-integrated bionic knee
It’s connected to underlying bone, nerves, and muscle. It has a more natural gait, beats current prosthetics in tasks like climbing stairs – and feels more like your own leg.
Title: Tissue-integrated bionic knee restores versatile legged movement after amputation
Authors: Tony Shu, Daniel Levine, Seong Ho Yeon, Ethan Chun, Christopher C. Shallal, John McCullough, Rickard Brånemark, Matthew J. Carty, Marco Ferrone, Sean Boerhout, Alexander Ko, Corey L. Sullivan, Gloria Zhu, Michael Nawrot, Matthew Carney, Ged Wieschhoff, Gabriel Friedman, Hugh Herr
Read the Full Article.
2. Bone marrow transplant treats a fatal disease ALSP is a rare genetic condition caused by loss of microglia. Here, bone marrow transplants replaced the microglia, halted disease progression, and maintained cognition and the ability to walk.
Title: Microglia replacement halts the progression of microgliopathy in mice and humans
Authors: Jingying Wu, Yafei Wang, Xiaoyu Li, Pei Ouyang, Yuanyuan Cai, Yang He, Mengyuan Zhang, Xinghua Luan, Yuxiao Jin, Jie Wang, Yujie Xiao, Yuqing Liang, Fang Xie, Yousheng Shu, Jiong Hu, Chunkang Chang, Jieling Jiang, Dong Wu, Youshan Zhao, Taohui Liu, Yuxin Li, Xiaojun Huang, Yao Li, Junfang Zhang, Yuwen Cao, Xin Cheng, Ying Mao, Yanxia Rao, Li Cao, Bo Peng
Read the Full Article.
3. An emerging (pre-clinical) strategy for Alzheimer’s
Tau accumulates >10 years before Alzheimer’s is diagnosed, but there are no therapies that directly target it
This is a short peptide that wraps itself around Tau fibrils and breaks them – safely.
Title: How short peptides disassemble tau fibrils in Alzheimer’s disease
Authors: Ke Hou, Peng Ge, Michael R. Sawaya, Liisa Lutter, Joshua L. Dolinsky, Yuan Yang, Yi Xiao Jiang, David R. Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Romany Abskharon, Shixin Yang, Zhiheng Yu, Juli Feigon, David S. Eisenberg
Read the Full Article.
4. Why is exercise anti-cancer?
Mice that exercise suppress tumors, but – if those mice are treated with antibiotics – the gut microbiome is depleted and the effect is pretty much gone
It’s (at least partly) mediated by gut bacteria.
Title: Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Authors: Catherine M. Phelps, Nathaniel B. Willis, Tingting Duan, Amanda H. Lee, Yue Zhang, Daphne M. Rodriguez J, Surya P. Pandey, Colin R. Laughlin, Aaron B.I. Rosen, Alex C. McPherson, Jake H. Shapira, Simran K. Randhawa, Lee Hedden, Tanner G. Richie, Hallie M. Wiechman, Mackenzie J. Bender, Ina Nemet, Patrick A. Zöhrer, Rachel A. Gottschalk, Kathryn H. Schmitz, Steven J. Mullett, Stacy L. Gelhaus, Diwakar Davar, Hassane M. Zarour, Reinhard Hinterleitner, Thomas Mossington, Jonathan H. Badger, Richard R. Rodrigues, John A. McCulloch, Sonny T.M. Lee, Karl-Heinz Wagner, Maria G. Winter, Sebastian E. Winter, Jishnu Das, Joseph F. Pierre, Giorgio Trinchieri, Marlies Meisel
Read the Full Article.
5. A virus linked to Parkinson’s
Viruses are linked to a range of conditions : autoimmunity, Alzheimer’s disease – and Parkinson’s. It’s a small sample, but Human Pegivirus was found in the brain of 5/10 Parkinson’s patients vs. 0/14 controls.
Title: Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson’s disease
Authors: Barbara A. Hanson, Xin Dang, Pouya Jamshidi, Alicia Steffens, Kaleigh Copenhaver, Zachary S. Orban, Bernabe Bustos, Steven J. Lubbe, Rudolph J. Castellani, Igor J. Koralnik
hank you for reading! Let me know if I’ve missed anything
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