Axel Licha: Re-irradiation – An Urgent Need to Harmonize Dose Constraints
Axel Licha, Radiation Oncology Resident at Greater Paris University Hospitals, shared a post on LinkedIn:
“Re-irradiation: An Urgent Need to Harmonize Dose Constraints
Re-irradiation (reRT) is becoming more and more common in oncology, but how do you determine the right dose constraints to protect organs at risk?
An international survey published in July 2025 of 17 centres in 13 countries reveals:
- 6% of treatments are reRTs
- The median of the variations observed between centers reached 21% for cumulative dose constraints in near-Dmax, all locations combined, on 19 organs at risk analyzed
- Very heterogeneous approaches for tissue recovery factor (TRF), near-Dmax definition and PRV margins
- 81% of the centres are based on literature, but with more than 50 different references
Key Message:
The lack of standardization complicates the comparison of studies and can impact patient safety. The authors call for harmonization of calculation and reporting methods (EQD2Gy, α/β, TRF) to facilitate collaboration and reproducibility.”
Title: Reirradiation dose constraints in clinical practice: Results of an international survey
Journal: Radiotherapy and Oncology
Authors: Joep Strooma, Myriam Ayadi, Anja Aarberg, Vera Batel, Cemile Ceylan, Sinéad Cleary, Carlo Greco, Lone Hoffmann, Andrew Jackson, Colin Kelly, Charles Mayo, Chrysanthi Michailidou, Donna H. Murrell, Sarah Muscat, Christopher J.H. Paget, Kelly C. Paradis, Jaime Perez-Alija, Ellen Yorke, Ali Zaila, Nick Westr
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