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Raffaele Colombo: Phase 1b of BL-B01D1 in Esophageal Squamous Cell Carcinoma
Jul 11, 2025, 16:09

Raffaele Colombo: Phase 1b of BL-B01D1 in Esophageal Squamous Cell Carcinoma

Raffaele Colombo, Associate Director of Medicinal Chemistry at Zymeworks Inc., shared a post on X about a recent paper by Chang Liu et al. published in Nature Medicine:

Phase 1b of BL-B01D1 (EGFRxHER3 TOPO1i BsADC) in esophageal squamous cell carcinoma published in Nature Medicine.

2.5 mg/kg D1D8 Q3W, ORR=40% (21/53)
2.0 mg/kg D1D8 Q3W, ORR=15% (3/20)

No significant correlation between response and expression of EGFR, HER3, or both (small number of patients).”

Raffaele Colombo

Title: A bispecific antibody–drug conjugate targeting EGFR and HER3 in metastatic esophageal squamous cell carcinoma: a phase 1b trial

Journal: Nature Medicine

Authors: Chang Liu, Dan Liu, Yinghua Ji, Meili Sun, Shegan Gao, Xuelei Ma, Diansheng Zhong, Ji Zhu, Yanshuo Cao, Changsong Qi, Miao Zhang, Panpan Zhang, Ran Xue, Zhi Peng, Jun Zhou, Sai Ge, Ming Lu, Jiajia Yuan, Yakun Wang, Zhenghang Wang, Jian Li, Xiaotian Zhang, Yi Zhu, Hai Zhu, Sa Xiao, Jifang Gong, Lin Shen, Zhihao Lu

Read the full article.

Raffaele Colombo

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