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Eric K. Singhi and Jarushka Naidoo Highlighted Study On Pooled Analysis of Datopotamab Deruxtecan in patients with EGFR–mutated NSCLC
Eric K. Singhi and Jarushka Naidoo
Jun 13, 2025, 16:39

Eric K. Singhi and Jarushka Naidoo Highlighted Study On Pooled Analysis of Datopotamab Deruxtecan in patients with EGFR–mutated NSCLC

Eric K. Singhi, Thoracic Medical Oncologist at MD Anderson Cancer Center, shared a post on X by Jarushka Naidoo, Full Professor and Consultant Medical Oncologist at Royal College of Surgeons in Irelan, adding:

“Pooled data on Dato-DXd in EGFR+ NSCLC from TROPION-Lung05 + 01
117 pts, median 3 prior lines, 82% prior osimertinib
– ORR: 43%
– DOR: 7 mo
– PFS: 5.8 mo
Mucositis/stomatitis: 69%
Ocular events: 32%
ILD/pneumonitis: 4%”

Jarushka Naidoo

Quoting Jarushka Naidoo‘s post.

“What is the role of Dato-Dxd in EGFR+ NSCLC?
– pooled analysis TropionLung01+05
– 117pts (med. 3 lines)
– ORR 43%, mPFS 5.8m, mOS 15.6m
– 60% stomatitis, g3+ 9%
Reasonable option, though data not in the era of MARIPOSA+/-2″

Title: A pooled analysis of datopotamab deruxtecan in patients with EGFR–mutated NSCLC

Journal: Journal of Thoracic Oncology

Authors: Myung-Ju Ahn, Aaron Lisberg, Yasushi Goto, Jacob Sands, Min Hee Hong, Luis Paz-Ares, Elvire Pons-Tostivint, Maurice Pérol, Enriqueta Felip, Shunichi Sugawara, Hidetoshi Hayashi, Byoung Chul Cho, George Blumenschein Jr., Elaine Shum, Jong-Seok Lee, Rebecca S. Heist, Robin Cornelissen, Wen-Cheng Chang, Dariusz Kowalski, Hong Zebger-Gong, Michael Chargualaf, Wen Gu, Lan Lan, Paul Howarth, Richard Joseph, Isamu Okamoto

Read the full article.

Jarushka Naidoo

More posts featuring Eric K. Singhi and Jarushka Naidoo on OncoDaily. 

Aaron Lisberg Byoung Chul Cho cancer Dariusz Kowalski Dato-DXd EGFR-mutated NSCLC Elaine Shum Elvire Pons-Tostivint Enriqueta Felip Eric K. Singhi George Blumenschein Jr Hidetoshi Hayashi Hong Zebger-Gong Isamu Okamoto Jacob Sands Jarushka Naidoo Jong-Seok Lee Lan Lan Luis Paz-Ares Maurice Pérol MD Anderson Cancer Center Michael Chargualaf Min Hee Hong Myung-Ju Ahn OncoDaily Oncology osimertinib Paul Howarth Rebecca S. Heist Richard Joseph Robin Cornelissen Royal College of Surgeons Shunichi Sugawara TROPION TROPION/Lung05 Wen Gu Wen-Cheng Chang Yasushi Goto
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