Jana Ivanidze: Cu64DOTATATE for intraoperative meningioma detection
Jana Ivanidze, Physician/scientist at Weill Cornell Medicine, shared a paper she and her colleagues authored on X:
“New paper from our team – Cu64DOTATATE for intraoperative meningioma detection. While only a single case, it represents years of work.
This case report describes the first patient enrolled on our feasibility study NCT06377371 which will enroll a total of 20 patients with meningioma for preop PET MR, intraoperative tumor detection, and postop PET MR follow up. Thanks to Curium US LLC for funding support.
The idea is simple – we borrow a gamma probe from the breast surgeons (who use it for intraop sentinel node detection) to detect 511keV photons emitted from Cu64 annihilation reaction. This may help improve resection extent, key in meningioma. Goal for now is feasibility.
I first became obsessed with this idea after reading this paper from El Lakis et al
– why not use this in meningioma?
Challenging with Ga68 given its short half life.
Then Cu64DOTATATE came along, with a half life of 13h. And here we are.”
Authors: Jana Ivanidze et al.
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