Gustavo Viani: Could Radiation “Heat Up” Cold Tumors?
Gustavo Viani, Associate Professor at Faculty of Medicine of Botucatu, São Paulo State University (UNESP), shared on X:
“Could Radiation ‘Heat Up’ Cold Tumors? New Evidence in NSCLC!
Objective
Evaluate whether enhances immunotherapy efficacy in TMB-low, PDL1-null, or Wnt-mutated NSCLC
Methods
- Design: Phase 2 RCT (NCT02492568)
- Arms: Pembrolizumab ± SBRT (3x8Gy before ICI)
- Samples: 293 blood/tumor biospecimens
- Analyses: Multiomics, TCR-seq, GSEA, RECIST
Key Findings
- upregulated IFNγ, antigen processing and T/B cell activation at distant sites
- Clonal TCR expansion seen in tumors + blood
- PFS benefit in ‘cold’ tumors with SBRT-ICI combo
- Suggests abscopal priming and cold-to-hot TME conversion
Clinical implication: RT may unlock ICI resistance in cold NSCLC.”
Title: Combination of pembrolizumab and radiotherapy induces systemic antitumor immune responses in immunologically cold non-small cell lung cancer
Authors: Justin Huang, Willemijn S. M. E. Theelen, Zineb Belcaid, Mimi Najjar, Daphne van der Geest, Dipika Singh, Christopher Cherry, Archana Balan, James R. White, Jaime Wehr, Rachel Karchin, Noushin Niknafs, Michel M. van den Heuvel, Victor E. Velculescu, Kellie N. Smith, Paul Baas and Valsamo Anagnostou
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