Insight

Gustavo Viani: No Difference in Coronary artery disease Risk for Left- vs. Right-Sided Breast Cancer Treatment

Gustavo Viani/onconews.com.br

Oct 26, 2024, 12:49

Gustavo Viani: No Difference in Coronary artery disease Risk for Left- vs. Right-Sided Breast Cancer Treatment

Gustavo Viani, Associate Professor at the University of São Paulo, shared on LinkedIn:

“Modern Radiotherapy Shows no Difference in Coronary artery disease Risk for Left- vs. Right-Sided Breast Cancer Treatment.

Objective: To determine whether there is a difference in the risk of developing or worsening coronary artery disease (CAD) in breast cancer (BC) patients receiving left- versus right-sided external beam chemotherapy (EBRT)

Methods:

• Conducted a meta-analysis by reviewing studies from January 1999 to September 2022 (PubMed, Web of Science, Scopus)
• Included studies using a consistent metric to identify CAD.
• Computed the risk ratio (RR) using a random effects model
• Analyzed an institutional cohort of high cardiovascular-risk BC patients (2010-2022), applying a Cox proportional hazards model

Results:

• Meta-analysis of 9 studies: Left-sided BC patients had a 10% increased risk of CAD compared to right-sided (RR: 1.10, 95% CI: 1.02-1.18, P = .01).
• Subgroup analysis (6 studies, post-1980 diagnoses): No significant difference in CAD risk based on BC laterality (RR: 1.07, 95% CI: 0.95-1.20, P = .27)
• Institutional cohort: No significant difference in CAD risk for left- vs right-sided BC (HR: 0.73, 95% CI: 0.34-1.54, P = .402).”

Gustavo Viani

Gustavo Viani, MD is an Associate Professor in the Department of Medical Imaging, Hematology, and Oncology at Hospital das Clínicas, Faculty of Medicine of Ribeirão Preto, University of São Paulo (FMRP-USP). Dr. Viani’s research focuses on radiation oncology, with expertise in brachytherapy, stereotactic radiosurgery, dose fractionation, radiation tolerance, and overall oncology practices.