Esosa Omoregie: Our lab’s latest work on Aquaporin 12 expression in the Stomach and Liver of the Spiny Dogfish
Esosa Omoregie, Graduate Research And Teaching Assistant at Georgia Southern University, shared a post on LinkedIn about a recent paper by him and colleagues published in Journal of Marine Science and Engineering:
“Excited to share that our lab’s latest work, ‘Aquaporin 12 Is Expressed in the Stomach and Liver of the Spiny Dogfish (Squalus acanthias),’ has been published!
This study uncovers the fascinating expression patterns and localization of Aquaporin 12 (AQP12) in the spiny dogfish, shedding light on its potential role in secretory processes and digestive physiology.
Our findings revealed AQP12 expression predominantly in the liver, stomach, and esophagus, with immunohistochemical evidence showing its presence in secretory granules similar to pancreatic zymogen granules in mammals. These insights pave the way for broader applications in understanding aquaporin function in both health and disease.
Aquaporins like AQP12 are integral to cellular transport mechanisms, making them attractive targets for therapeutic development. In particular, their roles in processes such as tumor growth and metastasis present exciting opportunities for pharmaceutical innovation, especially in cancer research.
Bridging these findings with drug discovery efforts could inspire novel approaches to tackle some of the most pressing challenges in oncology.
“Aquaporin 12 Is Expressed in the Stomach and Liver of the Spiny Dogfish (Squalus acanthias)”
Authors: Christopher Cutler, Jade Bender, Sarah Conner and Esosa Omoregie.
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