Emil Lagumdzic: Cancer doesn’t just evolve genomically – it evolves immunologically too
Emil Lagumdzic, Expert – Oncology and Hematology at Springer Medicine Austria, shared on LinkedIn about a recent paper by Shogo Kumagai et al. published in Science Immunology:
“Cancer doesn’t just evolve genomically – it evolves immunologically too.
Just read an interesting review on immunogenomic cancer evolution, highlighting how genetic mutations don’t just drive tumor growth but actively shape an immunosuppressive microenvironment (TME).
In EGFR-mutated lung cancer, for example, the immune system isn’t just evaded – it’s actively suppressed through recruited immunosuppressive cells.
This challenges the traditional cancer immunediting hypothesis and raises important questions:
- How do genetic mutations dictate immune evasion?
- Can targeted therapies help reverse immunosuppression and improve immunotherapy outcomes?
The concept of immunogenomic precision medicine—combining immunotherapy with targeted agents – could be a game-changer. Let’s see how this evolves in clinical practice!”
Immunogenomic cancer evolution: A framework to understand cancer immunosuppression
Authors: Shogo Kumagai, Yusaku Momoi, and Hiroyoshi Nishikawa
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