The oncology community mourns the passing of Brian Andrew Van Tine, MD, PhD, a world-renowned sarcoma expert, devoted clinician, and mentor, who passed away on November 8, 2025, at the age of 53, following a brief and challenging illness.
Dr. Brian Van Tine served as Professor of Medicine and Pediatrics at the Washington University School of Medicine in St. Louis and as Director of Developmental Therapeutics (Phase I) at the Siteman Cancer Center. A respected leader in both sarcoma research and early-phase clinical trials, he transformed the landscape of rare cancer treatment through his pioneering work and relentless dedication to patient care.
Early Life and Education
Born in Phoenix, Arizona, Dr. Van Tine demonstrated brilliance and creativity from a young age. He earned dual bachelor’s degrees in chemistry and biochemistry, with a minor in music, from the University of Arizona, before pursuing his MD and PhD at the University of Alabama in Birmingham.
After completing his residency and fellowship in internal medicine and oncology at Washington University and Barnes-Jewish Hospital, he joined the institution’s faculty, where his commitment to both research and clinical excellence quickly became evident.
Building a World-Class Sarcoma Program
Dr. Brian Van Tine joined the Division of Oncology in 2011 and became Director of the Sarcoma Program at Siteman Cancer Center, developing one of the leading sarcoma programs in the United States. His work in tumor metabolism and novel therapeutic development advanced understanding of rare and difficult-to-treat cancers.
In 2021, he was appointed Director of Developmental Therapeutics (Phase I), where he reorganized and expanded the early-phase clinical trials program, introducing numerous first-in-human studies and strengthening WashU’s leadership in innovative oncology research.
“Brian was not only a brilliant scientist but also a compassionate clinician and an extraordinary mentor,” said Dr. Victoria Fraser, Chair of the Department of Medicine. “He was completely dedicated to his patients and used his research and creativity to identify new treatments that improved their quality of life and survival.”
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A Leader in Global Oncology
Dr. Brian Van Tine’s influence extended far beyond St. Louis. He contributed to international oncology efforts through service on committees for the National Cancer Institute (NCI), American Association for Cancer Research (AACR), American Society of Clinical Oncology (ASCO), and NRG Oncology.
He co-chaired multiple global sarcoma symposia and served on editorial boards of top journals, including the Journal of Clinical Oncology, Clinical Cancer Research, and the Annals of Oncology. His expertise made him a sought-after speaker at major scientific conferences worldwide.
“Brian’s work changed how we understand and treat sarcomas,” said Dr. Daniel Link, Director of the Division of Oncology and Deputy Director of the Siteman Cancer Center. “His influence will endure for decades to come.”
Yan Leyfman: Brian Van Tine – The Truly Great Ones Leave Us Far Too Soon
Yan Leyfman/LinkedIn
Mentor, Musician, and Friend
Beyond his scientific and clinical excellence, Dr. Brian Van Tine was admired for his kindness, mentorship, and infectious enthusiasm. He trained and inspired generations of physicians and scientists who now carry forward his vision for compassionate, innovative cancer care.
Outside of medicine, he was a talented musician, serving as the Lead Oboist for the Town and County Symphony Orchestra for several seasons. He enjoyed fine art, classical music, travel, and sharing his love for good food and great conversation with friends and colleagues.
He was often seen at the Fabulous Fox Theater’s Broadway Club, enjoying performances from the front row with his beloved spouse, Josh Hall.
Legacy and Remembrance
Dr. Brian Van Tine’s legacy endures through his groundbreaking research, his mentorship, and the countless patients and families whose lives he touched.
He is survived by his husband, Josh Hall; his mother, Carole Van Tine; his brother, Mathew Van Tine; and his extended family. He was preceded in death by his father, William Clinton Van Tine, and his brother, Eric Van Tine.
His life was a testament to passion, intellect, and humanity — a rare combination that leaves an indelible mark on oncology and on all who knew him.
“His curiosity, compassion, and creativity changed lives — and his legacy will continue to inspire the next generation of cancer researchers.”
Written by Nare Hovhannisyan, MD