DES Daughters Show No Increased Risk of Breast Cancer – The Netherlands Cancer Institute
The Netherlands Cancer Institute shared a post on LinkedIn:
“New research from the Netherlands Cancer Institute, conducted in collaboration with the Dutch DES Centrum, shows that women who were exposed to diethylstilbestrol (DES) in utero do not have an increased risk of breast cancer or other common cancers later in life.
The known increased risk of vaginal cancer (clear cell adenocarcinoma and squamous cell carcinoma) persists, even after age 50 – though this remains a rare diagnosis. These findings offer valuable clarity for both patients and clinicians, and support tailored follow-up care for this population.
This large nationwide cohort study followed more than 12,000 DES-exposed women. Their data were compared with unexposed sisters and the general population, using cancer registry data, PALGA (the Dutch pathology archive), and detailed questionnaires.
Based on these findings, Dutch experts are reviewing whether the current cervical/vaginal screening recommendations – which now stop at age 60 – should be extended for DES-exposed women.
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