Aug 11, 2025, 12:32
Cuomo’s Paradox Fundamentally Changes How We Understand Health
Cuomo’s Paradox is a recently introduced medical phenomenon that separates prevention from survivorship by recognizing that factors associated with disease risk may bear the opposite, or neutral, association with survival after diagnosis.
This reframing signals a fundamental shift in what is considered “healthy” with regard to cancer, cardiovascular conditions, and other chronic diseases.
The principle has implications for guideline development, clinical trial design, and quality metrics. Stratifying recommendations by disease state and stage could reduce contradictory advice, support patient-centered care, and sharpen endpoints in research.
When OncoDaily reached out for comment, Cuomo said,
“The paradoxical observations observed between disease risk and disease survival underscore the need for us to contextualize what we consider beneficial for human health by disease state.”
See more posts featuring Raphael E. Cuomo.
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