Collage photo of Caterina Sposetti and Paolo Tarantino
May 8, 2025, 09:34
Caterina Sposetti: CT scan analysis is an important and cost-effective tool to tailor therapy for oncologic patients
Caterina Sposetti, Medical Oncology Fellow at Dana-Farber’s Breast Oncology Center and Dana-Farber Zakim Center, shared a post by Paolo Tarantino, Research Fellow at Dana-Farber Cancer Institute, adding:
“Adiposity and muscle mass evaluation through CT scan analysis is an important and cost-effective tool to tailor therapy for oncologic patients in routine clinical practice, especially with advanced cancers–potentially reducing toxicities.”
Quoting Paolo Tarantino‘s post:
“ADCs: are we dosing them right? Likely not. In this body composition study of 48 patients with mBC receiving T-DXd, higher subcutaneous adipose tissue and higher BMI were associated with a 5-fold increase in dose reductions and reduced T-DXd activity.”
Title: Body composition metrics as a determinant of trastuzumab deruxtecan related toxicity and response
Journal: Nature Briefing: Cancer
Authors: Shiran Yaacobi Peretz, Rivka Kessner, Yael Bar, Amir Sonnenblick, Shir Lerner, Ariella Deutsch-Lukatsky, Karteek Popuri, Mirza Faisal Beg, Shlomit Strulov Shachar
Read the Full Article.
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