Omission of Surgical Axillary Staging in Clinically Node-Negative T1-T2 Breast Cancer: INSEMA Trial Findings
The results of the INSEMA trial were recently presented at SABCS24.
The INSEMA trial evaluated whether omitting surgical axillary staging in patients with clinically node-negative, T1-T2 invasive breast cancer could achieve noninferior outcomes compared to sentinel lymph node biopsy after a median follow-up of 6 years.
Axillary Surgery in Breast Cancer — Primary Results of the INSEMA Trial
Authors: Toralf Reimer, Angrit Stachs, Kristina Veselinovic, Thorsten Kühn, Jörg Heil, Silke Polata, Frederik Marmé, Thomas Müller, Guido Hildebrandt, David Krug, Beyhan Ataseven, Roland Reitsamer, Sylvia Ruth, Carsten Denkert, Inga Bekes, Dirk-Michael Zahm, Marc Thill, Michael Golatta, Johannes Holtschmidt, Michael Knauer, Valentina Nekljudova, Sibylle Loibl, Bernd Gerber.
Healthcare professionals shared their insights about the trial on social media:
“INSEMA Trial:
Omission of sentinel node biopsy (SLNB) in patients with clin node-neg early breast cancer did not result in inferior IDFS (at 6 yrs: 91.7 vs 91.9%). Suggests no SLNB may be for age 50+ with gr 1-2, ER+/HER2- tumors, up to 2 cm.”
“Dr. Singh draws nice comparisons between SOUND and INSEMA.”
“Cowabunga! Riding Breast Cancer’s Biggest Data’s Wave from SABCS24.
INSEMA: Skip SLNB safely in early BC! Non-inferior outcomes in low-risk patients (HR+/HER2-, G1-2, ≤5cm) with BCT. 5yr iDFS: 91.9% vs 91.7%, minimal axillary events.”
“SABCS24-INSEMA Trial. Rand +/- SLNBx for cT1-2N0 all ax U/S, lump/RT to breast only. N=5502. No difference in invDFS or OS. Very low LRF. Together with SOUND trial, appropriate to omit SLNBx for cT1N0 HR+ age >50.”
“General Session 2 at SABC24.
No axillary surgery versus axillary sentinel lymph node biopsy in patients with early invasive breast cancer and breast-conserving surgery: Final primary results of the Intergroup-Sentinel-Mamma (INSEMA) trial.”
-
ESMO 2024 Congress
September 13-17, 2024
-
ASCO Annual Meeting
May 30 - June 4, 2024
-
Yvonne Award 2024
May 31, 2024
-
OncoThon 2024, Online
Feb. 15, 2024
-
Global Summit on War & Cancer 2023, Online
Dec. 14-16, 2023