A Bold Step in the Fight Against Acute Myeloid Leukemia – IU Simon Comprehensive Cancer Center
IU Simon Comprehensive Cancer Center shared a post on LinkedIn about a recent article by Denggang Fu et al, published in Nature Communications:
“The cancer center’s Reuben Kapur, PhD, and Santhosh Kumar Pasupuleti, PhD, are taking a bold step in the fight against acute myeloid leukemia—by targeting both the cancer cells and the environment that protects them.
In a new study published in Nature Communications, the team identifies a loop involving IL-33 and IL1RL1 that helps leukemia stem cells survive and evade the immune system. This insight opens the door for a potential new treatment strategy aimed at stopping relapse and strengthening immune response.
Explore how this research could change the way we approach aggressive blood cancers.”
Title: Dual targeting of tumoral cells and immune microenvironment by blocking the IL-33/IL1RL1 pathway
Authors: Denggang Fu, Hua Jiang, Alan Long, Ella Harris, Hongfen Guo, Maegan L. Capitano, John Wrangle, Joshua R. Faust, Anilkumar Gopalakrishnapillai, Santhosh Kumar Pasupuleti, Baskar Ramdas, Reuben Kapur, Sonali P. Barwe, Nai-Kong V. Cheung, Sophie Paczesny
Read the Full Article on Nature Communications
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