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Niklas Klümper: ASCO abstracts on phase EV-202 results have just been released
May 25, 2024, 08:14

Niklas Klümper: ASCO abstracts on phase EV-202 results have just been released

Niklas Klümper, Resident in Urology and Researcher at the Institute for Experimental Oncology at the University Hospital Bonn, shared on X:

“Very exciting! ASCO abstracts on phase EV-202 results have just been released:

Anti-NECTIN4 Enfortumab vedotin with disappointing efficacy in biomarker-unselected population beyond urothelial carcinoma.

Confirmed ORR in
– esophageal cancer 18.2%
– gastric cancer 9.5%
– NSCLC: Non-squamous 14.0%, squamous 8.3%
– Breast: TNBC 19.0%, HR+/HER2- 15.6%

Substantially lower compared to single-agent EV efficacy in metastatic urothelial carcinoma is 40-45%!

Allcomer setting for EV seems not to work beyond UC!

We need biomarkers to tailor EV treatment! Pre-selection based on NECTIN4 expression could be relevant!”

Source: Niklas Klümper/X