Photo from Margherita Ambrosini/X
May 24, 2024, 00:14
Margherita Ambrosini: Rare and important subgroup of POLE/D1 proofreading deficient (pd) mCRC treated with ICIs across Europe, USA and Israel
Margherita Ambrosini, Medical Oncology resident at University of Milan, shared on X/Twitter:
“Excited and honored to can finally share our work about the rare and important subgroup of POLE/D1 proofreading deficient (pd) mCRC treated with ICIs across Europe, USA and Israel.
POLE/D1pd define a small (~1%) subgroup of ultramutated mCRC with excellent immune-sensitivity.
89% ORR
2y PFS 88% – 2y OS 86%.
Even higher than dMMR/MSI-H mCRC treated with ICIs – even after adjustment for baseline prognostic factors.
Who?
male sex
young age
POLD1 right sided, POLE right and left sided
atypical RAS mutations
exceptionally high TMB.
Possible cohexistence with dMMR/MSI-H status.
Crucial the selection of a proofreading deficient variant – TMB can help!”
Source: Margherita Ambrosini/X
