Myeloma Paper of the Day, May 13th, suggested by Robert Orlowski

Robert Orlowski, Director of Myeloma Section at MD Anderson Cancer Center, shared on X:

“Myeloma Paper of the Day: Study integrating molecular time and structural variants within early chromosomal duplications identifies pre-gain deletions in 9.4% of hyperdiploid (HD) patients without IgH translocations, challenging HDy as earliest somatic event.”

Source: Robert Orlowski/X

The biological and clinical impact of deletions before and after large chromosomal gains in multiple myeloma

Authors: Anthony Cirrincione, Alexandra Poos, Bachisio Ziccheddu, Marcella Kaddoura, Marc-Andrea Baertsch, Kylee Maclachlan, Monika Chojnacka, Benjamin Diamond, Lukas John, Philipp Reichert, Stefanie Huhn, Patrick Blaney, Dylan Gagler, Karsten Rippe, Yanming Zhang, Ahmet Dogan, Alexander Lesokhin, Faith Davies, Hartmut Goldschmidt, Roland Fenk, Katja Weisel, Elias Mai, Neha Korde, Gareth Morgan, Saad Usmani, Ola Landgren, Marc Raab, Niels Weinhold, and Francesco Maura.

Other insight by Robert Orlowski on OncoDaily.