Biagio Ricciuti: Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants

Biagio Ricciuti, Medical Oncologist at Dana-Farber Cancer Institute, shared on X/Twitter:

“Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants.

Multiple EGFR extracellular domain variants not associated with approved targeted therapies were sensitive to afatinib and dacomitinib in vitro
Two patients with glioblastoma with somatic EGFR G598V dimerization domain mutations showed responses to dacomitinib”

Read the article.
Source: Biagio Ricciuti/X
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