Samuel Hume: Interesting paper in Nature Immunology

Samuel Hume, a Researcher at the University of Oxford, recently shared on X:

“Really interesting paper in Nature Immunology today (Broquet et al.).

They found that people who recover from sepsis have a reduced cancer risk in the years that follow (vs. matched people with non-septic infections):

This was recapitulated in a controlled setting in mice – mice that recover from sepsis suppress tumours better than uninfected mice:

The mechanism depends on immune reprogramming in sepsis: macrophages trained during sepsis recruit and establish tissue-resident T cells, which go on to perform long-term cancer surveillance.”

Article: Sepsis-trained macrophages promote antitumoral tissue-resident T cells

Authors: Alexis Broquet, Victor Gourain, Thomas Goronflot, Virginie Le Mabecque, Debajyoti Sinha, Mitra Ashayeripanah, Cédric Jacqueline, Pierre Martin, Marion Davieau, Lea Boutin, Cecile Poulain, Florian P. Martin, Cynthia Fourgeux, Melanie Petrier, Manon Cannevet, Thomas Leclercq, Maeva Guillonneau, Tanguy Chaumette, Thomas Laurent, Christelle Harly, Emmanuel Scotet, Laurent Legentil, Vincent Ferrières, Stephanie Corgnac, Fathia Mami-Chouaib, Jean Francois Mosnier, Nicolas Mauduit, Hamish E. G. McWilliam, Jose A. Villadangos, Pierre Antoine Gourraud, Karim Asehnoune, Jeremie Poschmann and Antoine Roquilly

Source: Samuel Hume/X