Kefah Mokbel: Young onset breast cancer with germline BRCA Pathogenic Variants was associated with increased risk for all-cause mortality if diagnosed within 10 years after last childbirth

Kefah Mokbel, Chair of The Multidisciplinary Breast Cancer Program at London Breast Institute, shared on LinkedIn:

“These findings suggest that young onset breast cancer with germline BRCA Pathogenic Variants was associated with increased risk for all-cause mortality if diagnosed within 10 years after last childbirth, with risk highest for ER-positive Breast Cancer diagnosed less than 5 years post partum, and for ER-negative BC diagnosed 5 to less than 10 years post partum.

BRCA1 carriers were at highest risk for poor prognosis when diagnosed at 5 to less than 10 years post partum. No such associations were observed for BRCA2 carriers. These results should inform genetic counseling, prevention, and treatment strategies for BRCA PV carriers.”

Additional information.
Source: Kefah Mokbel/LinkedIn