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Robert Z. Orlowski: Nice review of tumor-intrinsic and -extrinsic resistance mechanisms to T-cell engagers
Mar 27, 2024, 00:40

Robert Z. Orlowski: Nice review of tumor-intrinsic and -extrinsic resistance mechanisms to T-cell engagers

Robert Z. Orlowski, Director of Myeloma Section at MD Anderson Cancer Center, posted on X/Twitter:

“Myeloma Paper of the Day: Nice review of tumor-intrinsic (loss of target antigen, MHC class I, preventing MHC class I:TCR co-stimulatory signaling) and -extrinsic resistance mechanisms (exhausted T cells & immunosuppressive TME) to T-cell engagers.

Read the paper.
Source: Robert Z. Orlowski/X