Wafik S. El-Deiry: Important preliminary signal of transient response in GBM with CAR-T cells

Wafik S. El-Deiry, Director of the Legorreta Cancer Center at Brown University, shared a post on X:

“Important preliminary signal of transient response in GBM with CAR-T cells:

CAR T-Cell-Mediated Responses in Recurrent Glioblastoma.

First-in-human Intraventricular CARv3-TEAM-E T Cells that secrete T-cell–engaging antibody molecule (TEAM) and target EGFR vIII in Recurrent Glioblastoma

‘Radiographic tumor regression was dramatic and rapid, occurring within days after receipt of a single intraventricular infusion, but the responses were transient in two of the three participants. (Funded by Gateway for Cancer Research and others; INCIPIENT number, NCT05660369. opens in new tab.)”‘

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Source: Wafik S. El-Deiry/X