Marco Donia: The ‘Influencers’ of Cancer Immunotherapy do not affect immunotherapy outcomes
Marco Donia, Associate Professor at National Center for Cancer Immune Therapy, Denmark, shared on LinkedIn:
“The ‘Influencers’ of Cancer Immunotherapy
NSAIDs (Eur J Cancer, Apr 2024) do not affect immunotherapy outcomes. NSAIDs are not influencers; they can be safely used with anti-PD-1.
What are the Influencers of Cancer Immunotherapy?
Factors that can (potentially) improve or impair the effects of Cancer Immunotherapy such as:
1. Drugs:
- Antibiotics (article 1 or article 2)
- Paracetamol
- Beta-blockers
- Proton pump inhibitors
- Immunosuppressive drugs – for obvious reasons
2. Environmental Factors:
3. Psychosocial Factors:
4. Diet and Body Composition:
- Dietary Fibers, Probiotics, and Microbiome (article 1 or article 2)
- Body Mass Index
- Physical Activity
5. Sex
6. Many others – please share in the comments section!
Sara Valpione and collaborators investigated the prognostic and predictive value for the usage of non-steroidal anti-inflammatory drugs in the EORTC 1325/KEYNOTE-054 phase III trial of pembrolizumab versus placebo in resected high-risk stage III melanoma.
Main finding: No association with recurrence-free survival, distant metastasis-free survival, or immune-related adverse events This paper is from a series of manuscripts (manuscript 1, manuscript 2) investigating associations of drugs usage and clinical outcomes in the KN-054 trial.
NSAIDs=non-steroidal anti-inflammatory drugs (like diclofenac, aspirin, ibuprofen).
(Figure from 2021 review published in Cell about the “influencers” of cancer immunotherapy, freely available.)”
Source: Marco Donia/LinkedIn