Oscar Tahuahua: First Prospective Study on Testicular Function After Immune-Checkpoint Inhibitors Treatment
Oscar Tahuahua, Medical Oncology Fellow at the National Cancer Institute of Mexico, shared a post on X:
“First prospective study “Testicular Function After Immune-Checkpoint Inhibitors Treatment”
26 men (19–46y, Melanoma, 2 centers🇦🇺)
Do ICIs impair male fertility?
Evaluated semen + hormones before vs during treatment.
Results: -Total sperm: 193M→127M (↓34%, p=0.053) -Concentration: 61→43 M/mL (↓30%, p=0.075) -Motility & morphology: unchanged (NS) -FSH ↑ (p=0.04) → NS after excluding 1 azoospermia (<5%, autoimmune orchitis).
Modest, heterogeneous gonadal effect.
Consider sperm banking before ICIs and hormonal monitoring.”
Title: Testicular Function After Immune-Checkpoint Inhibitors Treatment
Authors: Andrea Boutros, Amanda Idan, Sue Sleiman, Feyrous Bacha, Ting Zhang, Veena Jayadev, Alexander M. Menzies, Georgina V. Long, David J. Handelsman
Read the Full Article.
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